Search for dissertations about: "insulin- like growth factor-1"
Showing result 11 - 15 of 65 swedish dissertations containing the words insulin- like growth factor-1.
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11. Aspects of regular long-term endurance exercise in adolescents, with focus on cardiac size and function, hormones, and the immune system
Abstract : The long-term effects of starting high-intensity training at younger ages are largely unknown. The present studies focused on adolescents who had performed regular endurance exercise for several years at an elite level and compared those subjects with a control group of adolescents of similar age and sex who had not engaged in regular exercise. READ MORE
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12. The effects of growth hormone on opioid-induced toxicity in vitro
Abstract : There is an ongoing opioid crisis in the United States that is portrayed by a large number of opioid-related deaths. Many of these cases involve commonly used prescription opioids, such as morphine, oxycodone, fentanyl, and methadone. This is concerning and highlights the problems associated with long-term opioid treatment. READ MORE
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13. Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth
Abstract : Several studies have demonstrated that mevalonate (MVA) synthesis is required for cell proliferation. The mechanisms underlying MVA-regulated cell growth are still not fully understood. One conceivable mechanism for MVA-dependent cell growth is N-linked glycosylation of growth regulatory proteins. READ MORE
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14. Testosterone, 17β-estradiol and pubertal growth
Abstract : Background and aims: It is well established that the interaction of sex steroids with the growth hormone (GH)/ insulin-like growth factor 1 (IGF-1) axis is of major importance in children for normal pubertal growth. However, detailed understanding is still lacking. READ MORE
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15. Importance of insulin-like growth factor-1 receptor and EWS/FLI-1 fusion protein in growth and survival of two different types of neuroectodermal tumor cells
Abstract : Treatment with comparatively low doses of the 3-hydroxy-3-metylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin caused growth arrest in both melanoma cells and Ewing's sarcoma (ES) cells. In melanoma cells growth inhibition was correlated with a drastic decrease in N-linked glycosylation of the insulin-like growth factor-1 receptor (IGF-1R), which in turn was followed by a decreased expression of IGF-1 binding sites at the cell surface. READ MORE