Search for dissertations about: "insulin- like growth factor-1"

Showing result 21 - 25 of 65 swedish dissertations containing the words insulin- like growth factor-1.

2. 21. Growth hormones in chronic kidney disease

   Author : Erik Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Several hormonal systems are disrupted in chronic kidney disease (CKD) and disturbances of the growth hormone axis could contribute to increased morbidity and mortality through effects on cardiovascular health, energy metabolism and inflammation. The overall aim of this thesis was to increase knowledge about hormonal alterations and their consequences in CKD, focusing on cardiovascular disease (CVD), mortality and the growth hormone axis in end-stage renal disease. READ MORE

4. 22. Growth factor pathways in human cancer : functional and therapeutic implications

   Author : Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
   Keywords : IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

   Abstract : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. READ MORE

5. 23. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

   Author : Elisabeth Björntorp Mark; Göteborgs universitet; []
   Keywords : IGF1R; GH; Id1; keratinocytes; psoriasis;

   Abstract : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. READ MORE

6. 24. Biomolecular Aspects of Flexor Tendon Healing

   Author : Maria Berglund; Monica Wiig; Olof Nilsson; Jan Fridén; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flexor tendon healing; Growth factor; Metalloproteinase; Collagen; Proteoglycan; Myofibroblast; Hyaluronan synthase; Mast cell; Hand surgery; Handkirurgi; Orthopaedics; Ortopedi;

   Abstract : Flexor tendon injuries in zone II of the hand (i.e. between the distal volar crease and the distal interphalangeal joint) can be costly for both the afflicted individual and society because of the high cost of a long rehabilitation period, complicated by tendon ruptures or scarring with adhesion formation, causing impaired range of motion. READ MORE

7. 25. Influence of antipsychotic drugs on hormone levels

   Author : Kristina Melkersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : antipsychotic agents; prolactin; growth hormone; insulin-like growth factor 1; insulin; leptin; lipids; side effects; weight gain; metabolic syndrome;

   Abstract : The aim of the studies summarized in this thesis was to investigate the influence of antipsychotic drugs on hormone levels, in order to identify causes of hormonally related side effects of these drugs. The effect of antipsychotics on the prolactin (PRL) secretion, the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis and the glucose-insulin homeostasis was studied. READ MORE