Search for dissertations about: "insulin-like growth factor 1"

Showing result 16 - 20 of 155 swedish dissertations containing the words insulin-like growth factor 1.

2. 16. The effects of growth hormone on opioid-induced toxicity in vitro

   Author : Erik Nylander; Mathias Hallberg; Alexis Bailey; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; opioids; methadone; morphine; ketobemidone; fentanyl; oxycodone; hydromorphone; insulin-like growth factor; cell viability; NG108-15; SH-SY5Y; hippocampus; cortex; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : There is an ongoing opioid crisis in the United States that is portrayed by a large number of opioid-related deaths. Many of these cases involve commonly used prescription opioids, such as morphine, oxycodone, fentanyl, and methadone. This is concerning and highlights the problems associated with long-term opioid treatment. READ MORE

4. 17. Molecular studies of the insulin-like growth factor system in the brain : focus on growth, tumorigenesis and trauma

   Author : Ann-Christin Sandberg Nordqvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : insulin-like growth factors; insulin-like growth factor binding proteins; brain; mRNA; meningioma; glioma; traumatic brain injury; in situ hybridization; Northern blothybridization;

   Abstract : Insulin-like growth factor (IGF) 1 and -2 are synthesized by most tissues of the body and function as autocrine or paracrine agents in a tissue-specific manner. mRNA for IGF-1 and -2, as well as the IGF-binding proteins, are synthesized locally in various regions of the brain. READ MORE

5. 18. Pre-, peri- and postnatal influences on ophthalmologic outcome - a study on children born after intracytoplasmic sperm injection (ICSI) and children born preterm

   Author : Margareta Hök Wikstrand; Göteborgs universitet; []
   Keywords : visual function; intracytoplasmic sperm injection; preterm birth; growth; insulin-like growth factor 1; postnatal development; ocular fundus morphology;

   Abstract : The aims of the present study were to investigate the effects of prenatal factors in children born after intracytoplasmic sperm injection (ICSI) and peri- and postnatal factors in children born preterm on visual function and ocular fundus morphology at school age. In the children born preterm the ophthalmologic outcomes, including optic nerve morphology were analysed in relation to gestational age (GA), birth weight (BW) standard deviation score (SDS), serum levels of insulin-like growth factor I (IGF-I), weight at week 32 (SDS), and weight, length and head circumference (SDS) at school age. READ MORE

6. 19. Cardiovascular effects of growth hormone. Studies in genetically engineered mice

   Author : Irene Andersson; Göteborgs universitet; []
   Keywords : acromegaly; autonomic nervous system; cardiovascular disease; cardiac function; vascular function; growth hormone; heart rate variability; hypertension; insulin-like growth factor-1; transgenic mice;

   Abstract : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. READ MORE

7. 20. GH, IGF-1 and insulin in the regulation of lipid and lipoprotein metabolism

   Author : Fredrik Frick; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth-hormone; insulin-like growth factor-I; insulin; lipoprotein lipase; adipose tissue; muscle tissue; VLDL secretion;

   Abstract : It is well known that growth hormone (GH) has profound effects on lipid and lipoprotein metabolism. Insulin-like growth factor-I (IGF-I) is believed to mediate some of the effects of GH via endocrine and paracrine mechanisms. Moreover, both GH and IGF-I are known to influence insulin secretion. READ MORE