Search for dissertations about: "insulin-like growth factor binding protein 1"

Showing result 21 - 25 of 57 swedish dissertations containing the words insulin-like growth factor binding protein 1.

  2. 21. Effects of growth factors on chondrocyte proliferation and differentiation

    Author : Caroline Edwall-Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Growth plate cartilage; limb buds; growth factors; proliferation; differentiation; collagens; c-fos; ALP;

    Abstract : Longitudinal bone growth is regulated at the level of growth plate chondrocytes by circulating or locally produced hormones and growth factors. Present investigation focused on the effects of growth hormone (GH) and growth factors on chondrocyte proliferation and differentiation during pre- and postnatal cartilage development. READ MORE

  4. 22. Diabetic osteopathy : a study in the rat

    Author : Tashfeen Ahmad; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Diabetes mellitus type 2; Goto-Kakizaki rat; bone mineral density; insulin-like growth factor-I; insulin-like growth factor binding protein 1; insulin-like growth factor binding protein 4; peripheral neuropathy; substance P; calcitonin gene-related peptide; neuropeptide Y; Diabetes mellitus type 2;

    Abstract : The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 and 20 months, and 36 age-matched Wistar rats as controls. READ MORE

  5. 23. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

    Author : Elisabeth Björntorp Mark; Göteborgs universitet; []
    Keywords : IGF1R; GH; Id1; keratinocytes; psoriasis;

    Abstract : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. READ MORE

  6. 24. Maternal and neonatal anthropometry and growth factor expression and apoptosis in human placenta : a comparison between two populations

    Author : Shahzad Akram; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases, are key endocrine regulators of somatic growth and cellular proliferation. IGFs are involved in growth both pre- and postnatally. READ MORE

  7. 25. Targeting the GH/IGF-1 axis with novel, small molecule inhibitors

    Author : Linda Rosengren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The growth hormone (GH) / insulin-like growth factor (IGF) family of ligands, binding proteins and receptors play multiple roles in cell growth, metabolism and development. In addition, numerous studies have demonstrated the pathophysiological importance of the GH/IGF-1 axis. READ MORE