Search for dissertations about: "insulin-like growth factor binding protein 1"

Showing result 6 - 10 of 57 swedish dissertations containing the words insulin-like growth factor binding protein 1.

  2. 6. The insulin-like growth factor system : effects of circulating proteases

    Author : Sara Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The insulin-like growth factor-I and -II (IGF-I/-II) are peptide hormones important for growth and metabolism. They stimulate cell proliferation and differentiation and inhibit apoptosis. In addition, they have insulin-like effects on glucose and amino acid metabolism. READ MORE

  4. 7. Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation

    Author : Henric Zazzi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGF binding proteins IGFBP ; DNA sequencing; chromosomal localization; gene expression; Sp I; NF-kappa-B; methylation;

    Abstract : Insulin-like growth factors (IGF-I and IGF-II) are among the more abundant growth factors isolated from bone tissue and are synthesized by various bone cells including osteoblasts. The activity of IGFs is controlled by a family of binding proteins (IGFBPs) divided into subfamilies depending on their individual affinity for IGFs. READ MORE

  5. 8. Regulation and actions of insulin-like growth factor binding proteins in vascular smooth muscle cells

    Author : Thomas Gustafsson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Insulin-like growth factor-I (IGF-I) has multiple actions on vascular smooth muscle cell (VSMCs) function. In the circulation and in extracellular fluids, IGF-I is complexed to high affinity IGF-binding proteins (IGFBPs), which modulate IGF-I bioactivity. The present study focused on expression and regulation of IGFBPs in VSMCs. READ MORE

  6. 9. Molecular studies of the insulin-like growth factor system in the brain : focus on growth, tumorigenesis and trauma

    Author : Ann-Christin Sandberg Nordqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : insulin-like growth factors; insulin-like growth factor binding proteins; brain; mRNA; meningioma; glioma; traumatic brain injury; in situ hybridization; Northern blothybridization;

    Abstract : Insulin-like growth factor (IGF) 1 and -2 are synthesized by most tissues of the body and function as autocrine or paracrine agents in a tissue-specific manner. mRNA for IGF-1 and -2, as well as the IGF-binding proteins, are synthesized locally in various regions of the brain. READ MORE

  7. 10. Cardiovascular effects of growth hormone. Studies in genetically engineered mice

    Author : Irene Andersson; Göteborgs universitet; []
    Keywords : acromegaly; autonomic nervous system; cardiovascular disease; cardiac function; vascular function; growth hormone; heart rate variability; hypertension; insulin-like growth factor-1; transgenic mice;

    Abstract : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. READ MORE