Search for dissertations about: "insulin-like growth factor binding proteins"

Showing result 1 - 5 of 39 swedish dissertations containing the words insulin-like growth factor binding proteins.

  2. 1. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

    Author : Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Insulin-like growth factor;

    Abstract : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. READ MORE

  4. 2. Insulin-like growth factor binding protein-3 : structure and function

    Author : Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Insulin-like growth factor (IGF) -I and -II share structural homology with insulin. Their receptors and intracellular signaling are similar. Consequently, the biological actions of IGFs and insulin are overlapping. Insulin is secreted on demand depending on e. READ MORE

  5. 3. Novel insulin-like growth factor-binding protein proteases : detection and characterization

    Author : Jing Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

    Abstract : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. READ MORE

  6. 4. Regulation of insulin-like growth factor-II in human liver

    Author : Henrik von Horn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IG17-II; IGF2; IGFBPs; liver; hepatoblastoma; GH; hypoxia;

    Abstract : Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented in conditions associated with elevated IGF-II precursor forms in the circulation. READ MORE

  7. 5. Insulin-like growth factor-II : cellular effects through different receptors

    Author : Qimin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Insulin-like growth factor-II (IGF-II) and IGF-I are single-chain polypeptides structurally homologous to proinsulin and share similarities with insulin in functional characteristics. Cellular actions of IGF-II are generally thought to be mediated through the IGF-I or insulin receptors, but not the IGF-II receptor, which is a single chain protein, identical to the cation independent mannose 6-phosphate (M6P) receptor and responsible for lysosomal enzyme targeting and degradation of IGF-II. READ MORE