Search for dissertations about: "integrin conformation"

Found 5 swedish dissertations containing the words integrin conformation.

2. 1. Structural and Functional Aspects of β1 Integrin Signalling

   Author : Stina Nilsson; Staffan Johansson; Teet Velling; Maria Fällman; Uppsala universitet; []
   Keywords : Cell and molecular biology; Integrin; Integrin subunit β1; Integrin activation; Threonine; Phosphorylation; Integrin signalling; FAK; PI3K; MAPK; Cell- och molekylärbiologi;

   Abstract : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. READ MORE

4. 2. Functional studies of integrin subunit 1 and its cytoplasmic domain

   Author : Krister Wennerberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; integrin; integrin subunit β1; integrin signaling; extracellular matrix; fibronectin polymerisation; focal adhesions; focaladhesion kinase; metastasis; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Abstract : Integrin subunit β1 can form functional heterodimeric receptors together with at least 11different a subunits. These integrins are the main cellular receptors for extracellular matrixproteins such as collagens, fibronectin, laminins, and others, and they are necessary fornormal embryonal development. READ MORE

5. 3. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

   Author : Shahram Hedjazifar; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

   Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE

6. 4. Role of integrin signaling in cell proliferation and survival

   Author : Wenjie Bao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Integrins function as transmembrane cell adhesion receptors for the surrounding extracellular matrix (ECM). Within the tissues, integrins attach the cells to the surrounding ECM and sense the ECM environment by triggering diverse arrays of signaling pathways that are essential for the control of many central cellular functions, including cell proliferation and survival. READ MORE

7. 5. Endogenous and microbial modulators of inflammation

   Author : Jamie D. Kraft; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; Resolution; Specialized pro-resolving mediators; Lipoxins; Neutrophils; Cardiometabolic disease; Next-generation probiotic; Oxygen-tolerance; Faecalibacterium prausnitzii; Desulfovibrio piger; Inter-strain variation;

   Abstract : Cardiometabolic disease is characterized by dysregulated, chronic inflammation, that may result from impaired resolution pathways or alterations in the gut microbiota. Thus, restoring specialized pro-resolving mediators (SPMs) or intestinal bacteria with immunomodulatory properties represent potential therapeutic strategies for patients. READ MORE