Search for dissertations about: "interethnic differences."

Showing result 1 - 5 of 6 swedish dissertations containing the words interethnic differences..

2. 1. Novel immunization strategies and interethnic differences in response to malaria infection

   Author : Charles Arama; Marita Troye-Blomberg; Kai Matuschewski; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Malaria; Immunization; Ethnic groups; vaccines; immunologi; Immunology;

   Abstract : A better understanding of the role of antigen-presenting cells (APCs) in host resistance to malaria is essential to unravel the complex interactions between the host and the parasite. This would improve the design of malaria vaccines. READ MORE

4. 2. Genetic polymorphism of xenobiotic metabolising enzymes : implications for interindividual and interethnic differences in drug metabolism and cancer susceptibility

   Author : Irene Persson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Lung cancer; drug metabolism; genetic polymorphism; cytochrome P450; CYPIAI; CYP2EI; CYP2D6; interethnic differences.;

   Abstract : Genetic factors are of importance for interindividual and interethnic differences in drug response and cancer susceptibility. In the present investigation the role of genetic polymorphism in the cytochromes P450 CYPIAI, CYP2C19, CYP2D6, CYP2EI as well as in glutathione S-transferase Ml (GSTMI) and microsomal epoxide hydrolase (mEH) for differences in drug response and cancer susceptibility has been investigated in various ethnic populations. READ MORE

5. 3. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor

   Author : Roman A McLellan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. READ MORE

6. 4. Single nucleotide polymorphisms related to immune responses in Plasmodium falciparum malaria

   Author : Amre Nasr; Klavs Berzins; Marita Troye-Blomberg; Gehad ElGhazali; Thor Theander; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; FcγRIIa-R H131; CRP genotypes; GM KM allotypes; IgG; and malaria; Sudan; Immunology; Immunologi; immunologi; Immunology;

   Abstract : The current research is directed towards dissection of host genetic factors involved in host immune response and the malaria disease outcome. A possible association between FcγRIIa polymorphism and anti-malarial antibody (A.M.A) responses were investigated in Sudanese patients in relation to clinical outcome of falciparum malaria. READ MORE

7. 5. Genetic polymorphism of human drug metabolising enzymes : structural and functional studies

   Author : Mikael Oscarson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : There is a pronounced interindividual variability in the levels and activity of many drug metabolising enzymes, which might cause differences in the sensitivity to and the toxicity of many clinically used drugs as well as environmental compounds such as nicotine and precarcinogens. In the present investigation the molecular genetic basis for some of the differences in the CYP2A6, CYP2D6, CYP2E1 and GSTM1 enzymes have been elucidated. READ MORE