Search for dissertations about: "interferon production"
Showing result 1 - 5 of 129 swedish dissertations containing the words interferon production.
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1. Functional and molecular aspects of interferon action in human natural killer cells and other leucocytes
Abstract : Interferons comprise a class of structurally related proteins which exert several regulatory effects in responsive cells. These effects include the establishment of an antiviral state, the inhibition of cellular proliferation and the alteration of different immune reactions. READ MORE
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2. Multiple Sclerosis: Studies of the Interferon system and search for infectious agents
Abstract : Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. READ MORE
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3. Autoantibodies and the Type I Interferon System in the Etiopathogenesis of Systemic Lupus Erythematosus
Abstract : In sera remitted for anti-nuclear antibody (ANA) analysis, the supplement of a sensitive anti-SSA/Ro ELISA to the conventional ANA screening by immunofluorescence (IF) revealed that one fourth of the individuals with IF-ANA negative, but SSA/Ro ELISA positive sera, had systemic lupus erythematosus (SLE) or cutaneous LE. Consequently, adding a sensitive anti-SSA/Ro ELISA to the ANA screening is valuable for the serological detection of ANA negative SLE/LE patients. READ MORE
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4. Mechanisms of Interferon-α Induction in Systemic Lupus Erythematosus
Abstract : Patients with systemic lupus erythematosus (SLE) have an activated type I interferon (IFN) system with an ongoing IFN-α synthesis. This may be caused by circulating immune complexes, consisting of anti-DNA antibodies (Abs) and DNA, with IFN-α inducing capacity. READ MORE
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5. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases
Abstract : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. READ MORE