Search for dissertations about: "interferon-α"

Showing result 1 - 5 of 19 swedish dissertations containing the word interferon-α.

  2. 1. Monoclonal antibodies to human interferon-α and interferon-γ : Characterization and application with focus on interferon-γ as a T cell cytokine

    Author : Gudrun Andersson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Abstract : The major functions of the immune system are to combat infections and to control that normal auto-immunity does not turn into auto-aggression. Antibodies, together with T cell receptors and MHC molecules, dictates the immunological specificity. READ MORE

  4. 2. Mechanisms of Interferon-α Induction in Systemic Lupus Erythematosus

    Author : Ullvi Båve; Lars Rönnblom; Gunnar V. Alm; Ingrid Lundberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; interferon inducer; apoptosis; autoantibodies; natural interferon-alpha producing cell; FcgammaRII; Sjögren´s syndrome; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

    Abstract : Patients with systemic lupus erythematosus (SLE) have an activated type I interferon (IFN) system with an ongoing IFN-α synthesis. This may be caused by circulating immune complexes, consisting of anti-DNA antibodies (Abs) and DNA, with IFN-α inducing capacity. READ MORE

  5. 3. Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus

    Author : Dag Leonard; Lars Rönnblom; Gunnel Nordmark; Maija-Leena Eloranta; Søren Jacobsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; Cardiovascular Disease; Intima-Media Thickness; STAT4; IRF8; Interferon-α; Plasmacytoid dendritic cell; GM-CSF; IL-3; Medicin; Medicine; Genetics; Genetik; Immunologi; Immunology;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. READ MORE

  6. 4. Gene Therapy with Interferon Alpha and the Angiogenic Inhibitor, Vasostatin, in Neuroendocrine Tumors of the Digestive System

    Author : Minghui Liu; Kjell Oberg; Yinghua Zhou; Bertram Wiedenmann; Uppsala universitet; []
    Keywords : Internal medicine; neuroendocrine tumor; interferon-α; vasostatin; vinculin; tumor suppressor gene; nude mice; gene therapy; Invärtesmedicin;

    Abstract : IFN-α has been applied in medical treatment of various neuroendocrine (NE) tumors, either alone or combination with somatostatin analogues. They can improve clinical symptoms in 50-70% of patients but a significant tumor reduction is only observed in 5-15% patients. Vasostatin (vaso) is believed to be an angiogenic inhibitor. READ MORE

  7. 5. Clinical and Experimental Studies in Primary Sjögren’s Syndrome and Systemic Lupus Erythematosus

    Author : Gunnel Nordmark; Lars Rönnblom; Olle Kämpe; Ola Winqvist; Lennart Jacobsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Sjögren’s syndrome; SLE; α-fodrin; interferon-α; single nucleotide polymorphism; dehydroepiandrosterone; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : Autoimmune mechanisms and genetic susceptibility contribute to the pathogenesis of primary Sjögren’s syndrome and SLE. These chronic systemic autoimmune diseases have many serological and clinical features in common and have an impact on daily life. READ MORE