Search for dissertations about: "interleukin 24"

Showing result 1 - 5 of 40 swedish dissertations containing the words interleukin 24.

  2. 1. Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis : Role of Inflammation and Oxidative Stress

    Author : Johanna Helmersson; Samar Basu; Bengt Vessby; Tommy Cederholm; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; prostaglandin F2α; F2-isoprostane; interleukin-6; C-reactive protein; serum amyloid A; tocopherols; cardiovascular risk factors; variation; inflammation; oxidative stress; human; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden;

    Abstract : Inflammation and oxidative stress may be involved in atherogenesis. This thesis describes clinical studies of prostaglandin F2α (PGF2α), an inflammatory mediator, and the isoprostane 8-iso-PGF2α, a reliable indicator of oxidative stress, and cytokine-related inflammatory mediators and indicators in healthy subjects and in a population-based cohort of Swedish men. READ MORE

  4. 2. Interleukin 6 trans-signalling : cardiovascular risk marker or therapeutical target?

    Author : Louise Ziegler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Interleukin (IL) 6 signals in two pathways. In classical signalling, essential in antimicrobial defence and tissue regeneration, IL6 binds the membrane- bound IL6 receptor (IL6R) which associates with the signal transducing receptor gp130. READ MORE

  5. 3. Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration

    Author : Charlotta Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traditionally, up-regulation and secretion of cytokines are associated with peripheral immune and inflammatory responses. There is now evidence that cytokines also exert various actions in the central nervous system (CNS). READ MORE

  6. 4. Cytokine profiles, infections and IgE sensitisation in childhood

    Author : Caroline Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Allergy; allergic heredity; childhood; cytokines; IgE-sensitisation; Epstein-Barr virus; interleukin-12; viral infections.;

    Abstract : Background: The etiologic factors behind development of lgE-mediated allergy are incompletely understood although the interaction between allergic heredity and exposure to various environmental factors seems to be most important. Objective: The overall aim of this thesis was to study the associations between allergic heredity, environmental factors like viral infections and lgE sensitisation and the development of allergic diseases during childhood. READ MORE

  7. 5. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease

    Author : Daniel Famer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Abstract : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE