Search for dissertations about: "interleukin-1 receptor antagonist"

Showing result 1 - 5 of 17 swedish dissertations containing the words interleukin-1 receptor antagonist.

  2. 1. Inflammation-Induced Gene Expression in Brain and Adrenal Gland

    Author : Linda Engström; Anders Blomqvist; Tomas Hökfelt; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; brain; adrenal gland; stress; lipopolysaccharide; interleukin-1; Neurobiology; Neurobiologi;

    Abstract : The autonomic nervous system serves to maintain a constant inner environment, a process termed homeostasis. Thus, in response to the homeostatic challenge posed by infectious agents, the autonomic nervous system answers to signals from the immune system and elicits adaptive physiological and behavioral reactions. READ MORE

  4. 2. Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity

    Author : Mircea Oprica; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Interleukin-1 (IL-1) is one of the most important pro-inflammatory cytokines and plays a pivotal role in the neuroinflammation associated with certain forms of neurodegeneration, such as epilepsy, cerebral ischemia, trauma, and Alzheimer's disease (AD). Also, it was suggested that IL-1 is involved in physiological processes, namely modulation of sleep, glucose and lipid metabolism, and neuroendocrine regulation, as well as modulation of learning and memory. READ MORE

  5. 3. Blocking interleukin-1 signalling in the brain-structural and functional outcomes

    Author : Stefan Spulber; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist with the GFAP promoter (Tg hsIL-1ra). READ MORE

  6. 4. The Interleukin-1 family of proteins in the brain and adrenal gland : regulation in response to bacterial LPS

    Author : Susanne Tingsborg; Fred J.H. Tilders; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Abstract : Interleukin-1 (IL-1) is mediating diverse physiological conditions as inflammatory response, fever and sickness behaviour but also, via activation of the hypothalamus-pituitary-adrenal (HPA)-axis, the release of the anti-inflammatory adrenocorticoids. The neuroendocrine system as well as the central nervous system (CNS) is involved in the regulation of these conditions in the body. READ MORE

  7. 5. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Author : Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Keywords : Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Abstract : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. READ MORE