Search for dissertations about: "intestine"

Showing result 1 - 5 of 302 swedish dissertations containing the word intestine.

  1. 1. Drug Transport and Metabolism in Rat and Human Intestine

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Berggren; Uppsala universitet.; [2006]
    Keywords : Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

    Abstract : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. READ MORE

  2. 2. Mucus associated proteins and their functional role in the distal intestine

    University dissertation from Göteborg : University of Gothenburg

    Author : Joakim H. Bergström; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestine; mucus; bacteria; MUC2; AGR2; FCGBP; ZG16;

    Abstract : The mammalian intestine, especially the large intestine, harbors complex societies of beneficial bacteria coexisting with the host. This is a mutualistic relationship, where the host provides nutrients and a favorable environment while the bacteria in return ferment indigestible polysaccharides to short chain fatty acids. READ MORE

  3. 3. The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine

    University dissertation from Göteborg : University of Gothenburg

    Author : Thaher Pelaseyed; Göteborgs universitet.; Gothenburg University.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestine; mucin; MUC3; MUC17; SEA; PDZK1; GOPC; CFTR; NHE3;

    Abstract : The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that protects luminal organs such as the gastrointestinal tracts from the outer milieu. READ MORE

  4. 4. Expression and regulation of CCL25 and its role in T cell localization to and function within the small intestine

    University dissertation from Lund University, Faculty of Medicine

    Author : Anna Ericsson; Lunds universitet.; Lund University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosa; epithelium; intestine; transplantation; serology; Immunologi; Immunology; integrin; serologi; Chemokine;

    Abstract : Earlier studies have demonstrated an important role for the chemokine CCL25, and its receptor CCR9, in the generation of the small intestinal lymphocyte compartment. The work in this thesis was aimed at determining how CCL25 is regulated within the small intestinal mucosa, and what potential role it plays in T cell localization to and function within this site. READ MORE

  5. 5. Profiling of Small Intestine Neuroendocrine Tumors

    University dissertation from Lund University, Faculty of Medicine

    Author : Ellinor Andersson; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine neuroendocrine tumor; somatic copy number alteration; expression profiling; APLP1; survival; targeted therapy;

    Abstract : Small intestine neuroendocrine tumors (SI-NETs) are malignant neoplasms usually presenting with disseminated disease and symptoms of hormone overproduction. Radical surgery is curative but can only be performed for localized disease. For most patients the disease follows a progressive and fatal course. READ MORE