Search for dissertations about: "intimal hyperplasia"

Showing result 1 - 5 of 28 swedish dissertations containing the words intimal hyperplasia.

  2. 1. On cellular sources for intimal hyperplasia after vascular interventions

    Author : Stefan Mellander; Göteborgs universitet; []
    Keywords : intimal hyperplasia; vascular intervention; smooth muscle cell; blood-born mononuclear cell; prosthetic graft; balloon injury; pig; rabbit;

    Abstract : Vascular interventions for the treatment of symptomatic atherosclerosis fail in up to 40 % of the cases during the first year. One important reason is the development of a narrowing process known as intimal hyperplasia (IH). The cells forming IH resemble smooth muscle cells (SMCs) from the media of the arterial wall. READ MORE

  4. 2. The role of the adventitia and perivascular tissue for the formation of intimal hyperplasia

    Author : Per Fogelstrand; Göteborgs universitet; []
    Keywords : Intimal hyperplasia; adventitia; perivascular tissue; smooth muscle cells; fibroblasts; balloon injury; vein graft; artificial graft;

    Abstract : Symptomatic atherosclerosis is commonly treated with balloon angioplasty or bypass surgery. About 30% of the interventions will re-narrow within a year due to restenosis and graft-stenosis. Thickening of the luminal layer, the intima, is an important component in these side-effects. READ MORE

  5. 3. Development of intimal hyperplasia in transplant arteriosclerosis

    Author : Piotr Religa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Vascular disease is the main cause of disability and mortality in the western world and the major limiting factor for long- term survival of transplanted organs. Occlusive vascular lesions lead to ischemia and structural changes in organs and in transplant arteriosclerosis and restenosis after endovascular procedures, narrowing of the vessel lumen is partly due to intimal hyperplasia caused by smooth muscle cells (SMCs). READ MORE

  6. 4. Basement membrane heparan sulfate in atherogenesis and intimal hyperplasia

    Author : Karin Tran Lundmark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiovascular disease due to atherosclerosis has become the leading cause of mortality in the world. Atherosclerosis is a progressive disease characterized by the accumulation of lipids, inflammatory cells, smooth muscle cells (SMCs) and extracellular matrix in the wall of large and medium-sized arteries. READ MORE

  7. 5. Vascular Wall Responses to Bypass Grafting - Studies in Mice

    Author : Klas Österberg; Göteborgs universitet; []
    Keywords : Intimal hyperplasia; graft stenosis; smooth muscle cells; mice; cellular recruitment;

    Abstract : Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia (IH). It is assumed that exaggerated intimal thickening is initiated by vessel wall injuries or local flow disturbances. READ MORE