Search for dissertations about: "intracellular Ca2 handling"
Showing result 1 - 5 of 12 swedish dissertations containing the words intracellular Ca2 handling.
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1. Dynamics of Ca2 handling in vascular smooth muscle
Abstract : Intracellular Ca2+ is a key regulator of vascular contractility, and thereby of blood perfusion and pressure. Ca2+ signals are essential also for cell migration, proliferation and regulation of numerous enzymes. READ MORE
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2. Regulation of Intracellular Calcium in Brown Adipocytes
Abstract : Intracellular Ca2+ is considered a primary regulator of cell function. In the present study, the control and the effects of intracellular Ca2+ in brown adipocytes have been investigated. Cytosolic Ca2+ levels ([Ca2+]i) are the resultant of the activity of Ca2+ transport systems. READ MORE
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3. Ca2+ fluxes and insulin action in cardiac and skeletal muscles
Abstract : Obesity and type 2 diabetes are major and rapidly increasing health problems in society. They are associated with several life-threatening conditions, including heart and renal failure, and damage to the nervous system. An inability of cells to respond normally to insulin, insulin resistance, is a key feature in obesity and type 2 diabetes. READ MORE
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4. Metabolic signals in the regulation of insulin release
Abstract : In the present thesis, an attempt was made to elucidate the role of some of the glucose-induced intracellular metabolic effector signals in insulin secretion and to develop new applications that will enable further investigations of oscillatory signalling and secretion from pancreatic ß-cells. The sequence of early metabolic and ionic events was examined in clonal pancreatic insulin secreting cells (HIT) in response to glucose stimulation. READ MORE
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5. Environmental input to the pancreatic β-cells - the role of mechanosensitive and other ion channels
Abstract : Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. READ MORE