Search for dissertations about: "intracellular"
Showing result 16 - 20 of 1531 swedish dissertations containing the word intracellular.
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16. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting
Abstract : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. READ MORE
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17. Innate immunity to intracellular bacterial infections
Abstract : Intracellular bacterial pathogens have developed mechanisms to enter and invade cells, to survive the immune response and to replicate inside the host. We studied the innate mechanisms that have evolved in the host to battle intracellular bacterial pathogens, such as the obligate intracellular Chlamydia pneumoniae and the facultative intracellular Listeria monocytogenes, which invade the respiratory and the gastrointestinal tracts in humans. READ MORE
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18. Host control of intracellular bacterial infections
Abstract : In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they can successfully grow. However, macrophages are potent killers of intracellular bacteria. READ MORE
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19. Nephrin cellular trafficking and intracellular interactions
Abstract : Nephrin is a 180-kDa transmembrane glycoprotein belonging to the immunoglobulin family of cell adhesion molecules. Nephrin has an extracellular part with eight Ig-like motifs, one fibronectin-like domain, a transmembrane region and a short cytoplasmic tail. READ MORE
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20. Nephrin : intracellular trafficking and podocyte maturation
Abstract : Congenital nephrotic syndrome of the Finnish type, CNF, is an autossomal recessive disorder caused by mutations in the NPHS1 gene and, consequently, in its product nephrin, a 180 kDa transmembrane protein belonging to the immunoglobulin superfamily of adhesion molecules. In kidneys, nephrin is located exclusively to the podocyte slit diaphragm and it has a key role in organising amd maintaining the renal ultrafiltation barrier. READ MORE