Search for dissertations about: "intracerebral injections"

Showing result 1 - 5 of 7 swedish dissertations containing the words intracerebral injections.

2. 1. Discordant Neural Xenografting: Analysis and Modulation of Immune Responses

   Author : Lena Cecilia Larsson; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; neurofysiologi; neurophysiology; neuropsychology; Neurology; immunosuppression; immunology; xenograft; pig; Parkinson s disease; intracerebral transplantation;

   Abstract : Transplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could be prevented. READ MORE

4. 2. Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors

   Author : Deniz Kirik; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adeno-associated virus; regeneration; neuroprotection; glial-cell-line-derived-neurotrophic factor; cell death; substantia nigra; dopamine; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; tyrosine hydroxylase; sensorimotor behavior; transplantation; gene therapy;

   Abstract : The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. READ MORE

5. 3. Neurobiological basis of the nicotine withdrawal reaction : an experimental analysis

   Author : Bengt E Hildebrand; Karolinska Institutet; Karolinska Institutet; []
   Keywords : rat; nicotine; nicotine withdrawal; behavior; locomotor activity; microdialysis; intracerebral injections; mesolimbocortical; dopamine; ventral tegmental area; nucleus accumbens; amygdala; immediate-early genes; c-fos;

   Abstract : The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects of many dependence-producing drugs. It consists of cell bodies in the ventral tegmental area (VTA) that project to e.g. the nucleus accumbens (NAC), the central nucleus of amygdala (CNA) and the medial prefrontal cortex. READ MORE

6. 4. Cerebral mechanisms in cardiovascular control : studies on haemorrhage and effects of sodium

   Author : Robert Frithiof; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This thesis describes experiments investigating the influence of the brain on cardiovascular adaptations to haemorrhage and excess sodium in conscious chronically prepared sheep. A continuous reduction in blood volume eventually activates a reflex that causes a fall in vascular resistance and heart rate and thereby also in arterial blood pressure. READ MORE

7. 5. Effects of influenza A virus infections and interferon-gamma on synapse formation and function in hippocampal neurons in culture

   Author : Johan Brask; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Influenza A virus; hippocampal neurons; interferon-gamma; electrophysiology; synapses.;

   Abstract : The central nervous system (CNS) can be the target for several infections that include those with RNA viruses. The parenchyma of the CNS is considered an immuneprivileged site since it is protected behind the blood-brain barrier, expresses no or only low levels of major histocompatibility complex (MHC) molecules and contains a paucity of antigenpresenting cells that prime an immune response. READ MORE