Search for dissertations about: "intranasal administration"

Showing result 16 - 20 of 26 swedish dissertations containing the words intranasal administration.

  2. 16. Myeloid cells in autoimmune diseases

    Author : Muhammad Sohel Mia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple Sclerosis (MS) and Type 1 Diabetes (T1D) are autoimmune diseases caused by dysregulation of the immune system. Monocytes/macrophages are myeloid cells that play a pivotal role in both induction and resolution of these diseases depending on the stage and microenvironment of disease course. READ MORE

  4. 17. Excitotoxic neurodegeneration in mouse brain : roles of immune cells and cytokines

    Author : Zhiguo Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Excitotoxic neurodegeneration is a common feature in many neurological diseases. However, the roles of immune cells and cytokines in this process are unclear. To address this issue, we used knockout (KO) mice deficient in various immune cells or cytokines in our studies. READ MORE

  5. 18. Immune and autoimmune responses to HIV-1 in mucosa and other tissues

    Author : Peter Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces. We studied the effects of a novel mucosal route, jet-injection, for induction of systemic and local responses. READ MORE

  6. 19. Mechanisms triggering the recruitment of mast cell progenitors to the lung and regulation of mast cell degranulation

    Author : Behdad Zarnegar; Jenny Hallgren; Madeleine Rådinger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Mast cell progenitors; Recruitment; Lung; Virus; Influenza; Innate immunity; Poly I:C; IL-33; VAAT; SLC10A4; Degranulation;

    Abstract : Mast cells stem from the bone marrow and migrate via the blood as mast cell progenitors. Upon arrival in peripheral tissues, they develop into mast cells. These rare immune cells have numerous granules that contain large amounts of pro-inflammatory mediators. READ MORE

  7. 20. DNA vaccines and bacterial DNA in immunity

    Author : Lisa Charlotta Bandholtz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccine; CpG DNA; antimicrobial peptides C. pneumoniae; Shigella spp;

    Abstract : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. READ MORE