Search for dissertations about: "intrinsic pathway"

Showing result 1 - 5 of 109 swedish dissertations containing the words intrinsic pathway.

2. 1. Streptococcal virulence and the coagulation system

   Author : Kristofer Wollein Waldetoft; Infektionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococci; virulence; coagulation; intrinsic pathway; evolution;

   Abstract : This thesis explores streptococcal virulence from both mechanistic and evolutionary perspectives, where the mechanistic studies focus on interactions with the human coagulation system. We describe interactions between streptococcal surface proteins and components of the intrinsic pathway of coagulation and the kallikrein-kinin system in human plasma, as well as to how these surface proteins are produced in different growth phases. READ MORE

4. 2. Regulation of hematopoiesis by the Smad signaling pathway

   Author : Ulrika Blank Savukinas; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; retroviral mediated gene expression; conditional knockout; hematopoietic stem cell; hematopoiesis; Transforming growth factor-beta; Smad signaling; Medicin människa och djur ;

   Abstract : Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. READ MORE

5. 3. The Wnt pathway in ventral midbrain dopaminergic differentiation

   Author : Diogo Ribeiro; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. READ MORE

6. 4. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors

   Author : Xiaoting Yang; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; Abeta; aggregation; kinetics; secondary nucleation;

   Abstract : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. READ MORE

7. 5. Neurochemical regulators of the septohippocampal pathway : role in spatial and aversive learning

   Author : Elin Elvander Tottie; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acetylcholine; muscarinic receptor; galanin; serotonin; 5-HT1A receptor; glutamate; NMDA receptor; water maze; passive avoidance; septum; hippocampus; learning; memory; spatial; aversive; emotional; cognition;

   Abstract : The aim of this thesis was to investigate the significance of major neurotransmitters in the septohippocampal pathway for hippocampal-dependent learning and memory. The cholinergic and GABAergic neurons in the medial septal/vertical limb of the diagonal band of Broca area (MS/vDB) projecting to the hippocampus, constitute the septohippocampal pathway, which has been implicated in a number of important functions such as attention, anxietylike behavior and hippocampal-dependent learning and memory. READ MORE