Search for dissertations about: "invasive fungal disease"

Showing result 1 - 5 of 8 swedish dissertations containing the words invasive fungal disease.

2. 1. Invasive fungal disease in immunocompromised hosts with focus on diagnostics

   Author : Helena Hammarström; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; invasive fungal disease; diagnosis; 1; 3-β-d-glucan; hematological malignancies; hematopoietic stem cell transplantation; HIV; lung transplant recipients; bronchiolitis obliterans syndrome;

   Abstract : Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised patients. Papers I and II included patients with hematologic disorders. READ MORE

4. 2. Diagnostic and clinical aspects of invasive fungal disease after allogeneic hematopoietic stem cell transplantation

   Author : Ola Blennow; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In paper I, 99 patients who received reduced-intensity conditioning (RIC) were followed with weekly fungal PCR during the first 100 days after HSCT. Patients with a positive fungal PCR result were randomized to either treatment with liposomal amphotericin B or no treatment. READ MORE

5. 3. Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention

   Author : Tobias Svensson; Honar Cherif; Martin Höglund; Jan Sjölin; Christine Wennerås; Uppsala universitet; []
   Keywords : Chronic lymphocytic leukemia; Immunodeficiency; Hypogammaglobulinemia; IgG subclass; Pneumococci; Pneumococcal vaccine; Polysaccharide vaccine; Protein-conjugate vaccine; Aspergillosis; Bronchoalveolar lavage; Invasive fungal disease; Pneumocystis jirovecii pneumonia; Myelodysplastic syndrome; Azacitidine; Eltrombopag; Thrombocytopenia; Thrombopoietin receptor; Oncology; Onkologi;

   Abstract : The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS).Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. READ MORE

6. 4. Catalytic and Structural Properties of Heme-containing Fatty Acid Dioxygenases : Similarities of Fungal Dioxygenases and Cyclooxygenases

   Author : Ulrike Garscha; Ernst Oliw; Per-Johan Jakobsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dioxygenase; prostaglandin H synthase; Gaeumannomyces graminis; Aspergilli; hydroperoxide isomerase; linoleate diol synthase; cytochrome P450; oxylipin; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Abstract : 7,8-Linoleate diol synthase (7,8-LDS) of the take-all pathogen of wheat, Gaeumannomyces graminis, converts linoleic acid to 8R-hydroperoxyoctadecadienoic acid (8-HPODE) by 8-dioxygenase activity (8-DOX), and further isomerizes the hydroperoxide to 7S,8S-dihydroxyoctadecadienoic acid (7,8-DiHODE) by hydroperoxide isomerase activity. Sequence alignment showed homology to prostaglandin H synthase (PGHS), and both enzymes share structural and catalytic properties. READ MORE

7. 5. Biofilm formation in invasive disease caused by fungus of the genus Candida

   Author : Srisuda Pannanusorn; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Candida species are ranked as the fourth leading cause of nosocomial bloodstream infection. The association of the infection with several risk factors has been reported. The most predominant risk factor, however, is the presence of an intravenous catheter in patients, which provides an artificial surface for Candida spp. READ MORE