Search for dissertations about: "invasive margin"

Showing result 1 - 5 of 10 swedish dissertations containing the words invasive margin.

2. 1. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer

   Author : Ingrid Ljuslinder; Beatrice Malmer; Håkan Hedman; Roger Henriksson; Irina Golovleva; Mef Nilbert; Umeå universitet; []
   Keywords : breast cancer; colorectal cancer; LRIG1; EGFR; ERBB2; invasive margin; onkologi; Oncology;

   Abstract : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). READ MORE

4. 2. Biological and histological factors as predictors in rectal cancer patients : A study in a clinical trial of preoperative radiotherapy

   Author : Annica Holmqvist; Xiao-Feng Sun; Gunnar Adell; Jan-Erik Frödin; Östergötlands Läns Landsting; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi;

   Abstract : With improved surgical techniques and preoperative radiotherapy (RT) the local recurrence rate in rectal cancer patients has been reduced, however the mortality rate is still high and there is a huge variation in the response to preoperative RT in patients with the same tumour stage. To improve patient’s survival, it is of great importance to identify good prognostic and predictive factors that help us to select the best suited patients for preoperative RT in the future. READ MORE

5. 3. Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer

   Author : Jingfang Gao; Xiao-Feng Sun; Richard Palmqvist; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carcinogenesis; genetic alterations; colorectal cancer CRC ; cysteine-histidine rich protein PINCH ; Inflammatory infiltration; Angiogenesis; lymphangiogenesis; Oncology; Onkologi;

   Abstract : Carcinogenesis is a progressive process involving multiple genetic alterations in tumor cells and complex interactions in the tumor-host microenvironment. To better understand the contribution of molecular alterations in tumor cells and stromal variables to the development of colorectal cancer (CRC) and identify prognostic factors, in this study we examined the clinicopathological and biological significance of stromal variables, including particularly interesting new cysteine-histidine rich protein (PINCH), inflammatory infiltration, angiogenesis and lymphangiogenesis, as well as hRAD50/hMRE11/hNBS1 proteins and hRAD50 mutation in tumor cell in CRC. READ MORE

6. 4. Suggested next steps to prevent cervical cancer after surgical treatment for high-grade cervical dysplasia

   Author : David Megyessi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The risk of cervical cancer among women treated for high-grade cervical dysplasia is more than twofold compared with the general population, and this risk remains elevated for over two decades. In Sweden, cervical cancer incidence is rising again and the risk of cervical cancer among women with a prior history of high-grade cervical dysplasia has increased since the 1960s. READ MORE

7. 5. Molecular Studies of Irradiation and SN-38 on Colorectal Cancer

   Author : Åsa Wallin; Xiao-Feng Sun; Joar Svanvik; Peter Naredi; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer CRC ; molecular changes; SN-38; Oncology; Onkologi;

   Abstract : Colorectal cancer (CRC) is one of most common cancer diseases worldwide. In Swedenapproximately 5,000 new cases of CRC are generated each year, which makes it the thirdmost common cancer disease among both men and women. The past decades ofimproved treatment strategies have considerably increased the five-year survival for CRCpatients. READ MORE