Search for dissertations about: "ion channel voltage clamp"

Showing result 1 - 5 of 20 swedish dissertations containing the words ion channel voltage clamp.

  1. 1. Studies of individual pancreatic -cells : Electrophysiological analysis of rhythmic behaviour and development of new techniques

    Author : Staffan Dryselius; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic beta-cells; insulin release; signal transduction; cytoplasmic calcium; oscillations; patch clamp; ATP-regulated potassium channels; voltage-dependent calcium channels; metabolism; calcium ion; strontium ion; manganese ion; wavelets; de-noising; pattern recognition; superfusion; solution changes; microscopic labelling; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The insulin concentration in blood varies periodically, which is believed to prevent down-regulation of the hormone receptors. Loss of the regular insulin oscillations is considered to be an early sign of developing diabetes. READ MORE

  2. 2. Polyunsaturated Fatty Acids Modifying Ion Channel Voltage Gating

    Author : Sara Börjesson; Fredrik Elinder; Klaus Benndorf; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Voltage-gated ion channels play fundamental roles in neuronal excitability and therefore dysfunctional channels can cause disease. Epilepsy is such a disease, affecting about 1% of the population and being characterized by synchronous electric activity of large groups of neurons leading to various types of seizures. READ MORE

  3. 3. Voltage-Sensor Domains of Ion Channels : Physiology, Regulation, and Role in Disease

    Author : Michelle Nilsson; Antonios Pantazis; Fredrik Elinder; Henry M. Colecraft; Linköpings universitet; []

    Abstract : Brain function depends on the ability of neurons to sense and respond to electricity, which is mediated by small modules in the neuronal membrane called voltage-sensor domains (VSDs). Disruption of VSD function can cause neurological disease such as epilepsy. READ MORE

  4. 4. Molecular aspects on voltage-sensor movement

    Author : Amir Broomand; Fredrik Elinder; Guiscard Seebohm; Linköpings universitet; []
    Keywords : Potassium channels; voltage-gated; chemistry; metabolism; physiology; patch-clamp techniques; oocytes; MEDICINE; MEDICIN;

    Abstract : Voltage-gated ion channels are fundamental for electrical signaling in living cells. They are composed of four subunits, each holding six transmembrane helices, S1-S6. Each subunit contains a voltage-sensor domain, S1-S4, and a pore domain, S5-S6. READ MORE

  5. 5. Applying the Pump and Leak Hypothesis. An experimental and theoretical investigation of the principles of ion regulation and excitability in the crustacean stretch receptor neuron

    Author : Sten Theander; Människan i rörelse: hälsa och rehabilitering; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; lobster; stretch receptor neuron; leak current; Q-current; K-Cl cotransporter; A-current; mathematical model; excitability; GABA channel; neurophysiology; ion regulation; neuropsykologi; Neurologi; neurofysiologi;

    Abstract : An invertebrate nerve cell preparation, the lobster stretch receptor neuron, was investigated with respect to maintenance of its resting voltage, intracellular ion concentrations and excitability using voltage clamp technique and ion-selective microelectrodes. It was found that the resting voltage (-65 mV) of microelectrode impaled cells is caused by (a) a homogenous population of K+ channels which we denoted as leak channels (b) an electrogenic and voltage-dependent Na-K pump current and (c) an inward microelectrode-induced "impalement" current carried mainly by Na+. READ MORE