Search for dissertations about: "ion-channel"

Showing result 1 - 5 of 82 swedish dissertations containing the word ion-channel.

  2. 1. Ion channel control of phasic insulin secretion

    Author : Xingjun Jing; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phasic insulin secretion; Diabetes; pancreatic β-cells; ClC chloride channel; exocytosis; CaV channel;

    Abstract : Glucose-stimulated insulin secretion exhibits a biphasic pattern. The mechanism underling biphasic insulin secretion is not fully understood, but consensus exists that an elevation in [Ca2+]i is required for both first- and second-phase insulin secretion. READ MORE

  4. 2. Polyunsaturated Fatty Acids Modifying Ion Channel Voltage Gating

    Author : Sara Börjesson; Fredrik Elinder; Klaus Benndorf; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Voltage-gated ion channels play fundamental roles in neuronal excitability and therefore dysfunctional channels can cause disease. Epilepsy is such a disease, affecting about 1% of the population and being characterized by synchronous electric activity of large groups of neurons leading to various types of seizures. READ MORE

  5. 3. Novel microfluidic methods for studies of ion channel function

    Author : Jon Sinclair; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; patch clamp; micro fabrication; ion channels; microfluidics; drug discovery; GABAA< sub> receptors; memory;

    Abstract : .... READ MORE

  6. 4. Studies of ligand- and temperature-gated ion channels using microfluidic methods

    Author : Maria Millingen; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; solution exchange; desensitization; temperature-gated; ion channel; temperature control; ligand-gated; TRPV1; GABAA receptor; microfluidics;

    Abstract : This thesis describes the studies of the GABAA receptor, a ligand-gated ion channel, and the ligand- and temperature-gated ion channel TRPV1. The desensitization behavior of both of these proteins has been studied for different conditions, using a microfluidic device for superfusion. READ MORE

  7. 5. A Solution Exchange Platform for Exposure of Cells to Chemical Waves

    Author : Jessica Olofsson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; waveform synthesis; solution exchange; cell signalling; patch clamp; receptor; high through-put; microfluidics; microfabrication; channel; chemical oscillations; ion channel; poly dimethylsiloxane ; drug discovery;

    Abstract : This thesis presents the development, characterization and suggested applications of a platform for controlling the chemical environment around a cell or a cell constituent. The platform is unique in its capability to combine rapid solution switching with precise timing and access to a manifold of solution environments. READ MORE