Search for dissertations about: "ionising"

Showing result 1 - 5 of 50 swedish dissertations containing the word ionising.

2. 1. Biomarkers of ionising radiation relevant to carcinogenesis : Dose, dose rate and LET dependency of the responses

   Author : Milagrosa López Riego; Andrzej Wojcik; Lovisa Lundholm; Alexandros G. Georgakilas; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionising radiation; low dose; low dose rate; linear energy transfer LET ; mixed beams; dose and dose rate effectiveness factor DDREF ; cancer; DNA damage response; biomarkers; molekylär biovetenskap; Molecular Bioscience;

   Abstract : A better understanding of the relationship between ionising radiation (IR) dose, dose rate and radiation quality, and the risk of stochastic effects would improve risk extrapolation from atomic bomb survivors’ data. Owing to insufficient statistical power of epidemiological studies to detect excess incidence of cancer following low doses of IR delivered at low dose rates (LDLDR), as typically encountered in most common human exposure scenarios, radiobiological experiments are fundamental to describe the biological effectiveness of LDLDR and to define the underlying molecular mechanisms. READ MORE

4. 2. On ionising radiation and breast cancer risk

   Author : Anders Mattsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ionising radiation; breast cancer induction; cancer induction; risk models; risk modification; pooled analysis; mammmographic screening; gained lost years of life;

   Abstract : Background: It is well known that exposure to ionising radiation increases the risk for breast cancer occurrence. However, better understanding of breast cancer risks in terms of dose-response relationships formulated according to radiobiological target theories, age-at-exposure patterns and temporal dependence are important for the understanding of the underlying biological mechanism of radiation carcinogenesis as well as for the concern about possible risks associated with the very low doses received from routine mammographic screening. READ MORE

5. 3. Effects of ionising and non-ionising radiation in cell systems and a rat model for immuno-therapy

   Author : Catrin Baureus Koch; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kirurgi; ortopedi; traumatologi; Neurology; traumatology; transplantation; Surgery; orthopaedics; cell cultures; abscopal effect; serologi; Immunologi; serology; Immunology; rat tumour model; radiation therapy; radiation sterilisation; pulsed electric fields; interferon-gamma; immuno-gene therapy; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; glioblastoma multiforme;

   Abstract : The most malignant brain tumour, glioblastoma multiforme (GBM), has an utterly bad prognosis. In spite of all available therapy, the mean survival time is less than a year. In the unique BRIGTT project (Brain Immuno Gene Tumour Therapy), patients at the Dept of Neurosurgery. READ MORE

6. 4. Exploring phenomena that affect the fate and impact of radioactive materials in the blue mussel

   Author : Benedict Jaeschke; Clare Bradshaw; Andrew Turner; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radioecology; ionising radiation; environmental protection; Mytilus edulis; bioaccumulation; dose-response; ecotoxicology; tritium; particle; hypoxia; marin ekotoxikologi; Marine Ecotoxicology;

   Abstract : Current protection of the marine environment from radiation is based largely on measuring, estimating and modelling accumulation and impact(s) of radionuclides in a few marine species. Using a relevant marine organism, this thesis focusses on investigating some poorly described phenomena that could cause deviations from predicted measurements. READ MORE

7. 5. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks

   Author : Karin Karlsson; Bo Stenerlöw; Jörgen Carlsson; Thomas Helleday; Uppsala universitet; []
   Keywords : Molecular biology; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionising radiation; high-LET; heat-labile sites; PFGE; Molekylärbiologi;

   Abstract : Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual cells and organisms. Defects in the DNA repair may lead to cell death or genomic instability and development of cancer. READ MORE