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Showing result 1 - 5 of 68 swedish dissertations matching the above criteria.

  2. 1. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    Author : Natalia Avaliani; Epilepsicentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemogenetics; iPS; iN; electrophysiology; gene and cell therapy; Epilepsy;

    Abstract : The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. READ MORE

  4. 2. Interplay between tick-borne encephalitis virus and the host innate immunity

    Author : Chaitanya Kurhade; Anna Överby Wernstedt; Nelson Gekara; Helen Lazear; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Flavivirus; IPS-1; Interferon; Viperin; mikrobiologi; Microbiology;

    Abstract : Flaviviruses are important emerging and re-emerging arthropod-borne pathogens that cause significant morbidity and mortality in humans. It consists of globally distributed human pathogens such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZIKV). READ MORE

  5. 3. Integration and function of new neurons generated from fibroblasts and adult neural stem cells in the pathological brain

    Author : James Wood; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurogenesis; neural stem cells; iNs; iPS cells; stroke; epilepsy; electrophysiology;

    Abstract : In Papers One through Six we have investigated the function and integration of “new” neurons – new neurons born from neural stem cells in the adult brain, and new neurons in the sense that they were generated from fibroblasts. Papers One and Two focused on the new neurons generated from neural stem cells in the SVZ and SGZ after pathological insults. READ MORE

  6. 4. Conifer chemical defense : Rugulation of bark beetle colonization and pheromone emission

    Author : Tao Zhao; Anna-Karin Borg-Karlson; Irena Valterova; KTH; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Picea abies; Ips typographus; Ceratocystis polonica; methyl jasmonate; windstorm; stress response; terpenes; phenols; colonization; pheromone emission; Plant and forest protection; Växt- och skogsskydd;

    Abstract : Terpenes and phenols are of importance in conifer defense against insects and pathogens. Knowledge about tree chemical defense is vital for developing practical methods to maintain healthy forests. READ MORE

  7. 5. Single cell analysis of iPS derived neural stem cells and neurons

    Author : Matti Lam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell connections. READ MORE