Search for dissertations about: "iron homeostasis"

Showing result 1 - 5 of 27 swedish dissertations containing the words iron homeostasis.

  2. 1. Mitochondrial Iron Metabolism : Study of mitoferrin in Drosophila melanogaster

    Author : Christoph Metzendorf; Maria Lind Karlberg; Kenneth Söderhäll; Martina Muckenthaler; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; iron; Drosophila; mitochondria; mitoferrin; ferritin; spermatogenesis; cell cycle; DFO; MRS12; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Abstract : Iron has a dualistic character. On the one hand it is essential for the life of most organisms, on the other hand it is involved in the generation of reactive oxygen species that are implicated in diseases and aging. READ MORE

  4. 2. Structural Insights into the Acquisition and Storage of Iron

    Author : Ulrika Schagerlöf; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Molecular biophysics; Molekylär biofysik; Structure chemistry; single particle; ferric reductase; human phagocyte superoxide-generating NADPH oxidase; frataxin; cryo electron microscopy; FRO2; iron homeostasis; iron acquisition;

    Abstract : It is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called frataxin. READ MORE

  5. 3. Heterocystous cyanobacteria, Dps proteins and H2 production

    Author : Christoph Howe; Karin Stensjö; Felix Howe; Nir Keren; Uppsala universitet; []
    Keywords : H2 production; Cyanobacteria; Dps; ferritin-like proteins; iron; nutrient limitation; oxidative stress; biofilm; photobioreactor; iron homeostasis; H2O2;

    Abstract : To mitigate climate change, CO2-emitting technologies have to be exchanged by renewable alternatives such as H2. H2 can be produced by cyanobacteria, but major efforts to enhance H2 production yields by genetic modifications or optimised cultivation conditions resulted in energetic photo-to-H2 conversion efficiencies of 4. READ MORE

  6. 4. Metal homeostasis as critical determinant for cellular fitness

    Author : Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. READ MORE

  7. 5. Oligomerization of human and bacterial frataxin : Structural and functional studies

    Author : Mostafa Abdalkhalik; Biokemi och Strukturbiologi; []
    Keywords : Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

    Abstract : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. READ MORE