Search for dissertations about: "iron overload"

Showing result 1 - 5 of 14 swedish dissertations containing the words iron overload.

  2. 1. Cadmium exposure and iron status

    Author : Agneta Åkesson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : environmental exposure; biological monitoring; bioavailability; pregnancy; cadmium; iron deficiency; hemochromatosis; dietary intake; soluble transferrin receptor; serum ferritin;

    Abstract : People are exposed to cadmium, a ubiquitous toxic metal, mainly via basic foods such as cereals and vegetables. Cadmium accumulates in the kidney, and renal tubular damage is considered the critical effect. Recently, association with osteoporosis at environmental exposure levels was indicated. READ MORE

  4. 2. Congenital Dyserythropoietic Anemia type III (CDA III) : diagnostics, genetics and morbidity

    Author : Maria Liljeholm; Anders Wahlin; Richard Rosenquist Brandell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; congenital dyserythropoietic anemia; KIF23; hereditary hemochromatosis; iron overload; flow cytometry;

    Abstract : The Congenital Dyserythropoietic Anemias (CDA) are rare hereditary hemolytic disorders with large bi- to multi-nucleated erythroblasts in the bone marrow. Hemolysis is negative in a direct antiglobulin test (DAT). Based on morphology and clinical picture, three major forms of CDAs, type I, II, and III have been defined. READ MORE

  5. 3. Importance of iron overload and steatosis in patients with chronic liver disease

    Author : Joel Marmur; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis deals with the importance of hepatic iron and fat deposition in the context of chronicliver disease, with special focus on the role of the S65C mutation in the hemochromatosis cryptogenic cirrhosis (CC) in patients evaluated for liver transplantation, the expressions of innate and adaptive immunity in non-alcoholic steatohepatitis (NASH), and the role of the ironregulatory hormone hepcidin in dysmetabolic iron overload (DIO). NAFLD is the most common liver disease in the Western world. READ MORE

  6. 4. Studies of proteins in heme and iron metabolism

    Author : Vijole Dzikaite; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Iron; Heme; IRE IRP; Liver; eALAS; HFE;

    Abstract : One aim of the study was to investigate the regulation of the murine erythroid isoform of aminolevulinate synthase (eALAS) protein involved in heme synthesis. Another aim was to characterize the structure of the rat hemochromatosis gene (HFE) gene and its expression in conjunction with other genes involved in the regulation of iron homeostasis during inflammation and iron overload in the rat liver. READ MORE

  7. 5. Clinical and experimental studies on HFE and other genes involved in iron homeostasis

    Author : Petra Holmström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hereditary hemochromatosis; iron overload; HFE gene mutations; porphyria cutanea tarda; HFE gene; iron metabolism-related genes; iron homeostasis; liver; inflammation; and hepatocellular carcinoma;

    Abstract : In this thesis, the clinical significance of HFE mutations was further investigated, and the molecular mechanisms underlying the disturbed iron homeostasis during hemochromatosis, inflammation and hepatocellular carcinoma were studied in experimental models. Hereditary hemochromatosis (HH) is a prevalent autosomal recessive iron overload disorder caused by increased intestinal absorption and deposition of iron in vital organs, leading to organ damage. READ MORE