Search for dissertations about: "islet amyloid polypeptide"

Showing result 11 - 15 of 21 swedish dissertations containing the words islet amyloid polypeptide.

  2. 11. Structural and functional aspects of islet amyloid polypeptide (IAPP) and its gene

    Author : Lars Christmanson; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 12. Innate immunity in diabetes mellitus. Complement components C4BP and C3 promote survival of β cells under metabolic challenges

    Author : Klaudia Kulak; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement System; Inflammasome; Islet Amyloid Polypeptide; Complement C3; C4b-binding protein C4BP ; Interleukin 1β; Autophagy-Related Protein 16 like 1; Diabetes mellitus; type 2;

    Abstract : The Complement system is a main effector mechanism of the innate immune system, acting to enhance clearance of pathogens, but also aids removal of biological debris from the body, including immunocomplexes, apoptotic/necrotic cells and protein aggregates. Complement regulators serve to prevent excessive inflammation and their interaction with the same materials targeted by the complement system results in ‘silent’ cleaning of wastes. READ MORE

  5. 13. Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models

    Author : Xiaohong Gu; Gunilla Westermark; Anders Olofsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; ATTR; ATTR amyloidosis; crystalline structure; aggrephagy; Drosophila melanogaster; Gal4-UAS; electron tomography; DAMS; SOHA; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). READ MORE

  6. 14. Mutational effects on protein structure and function

    Author : Jonas Carlsson; Persson Bengt; Uwe Sauer; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mutation; prediction; phenotypes; homology model; virtual screening; molecular dynamics; amyloid; cancer; membrane protein; Bioinformatics; Bioinformatik;

    Abstract : In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. READ MORE

  7. 15. Islet amyloid polypeptide in the control of food intake : an experimental study in the rat

    Author : Urban Arnelo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : body weight; glucose metabolism; IAPP; meal patterns; monoamines; neuropeptides; radioimmunoassay; rats; satiety;

    Abstract : Control of food intake and satiety are physiologically complex processes, that only partly are understood. Several hormonal peptides have been proposed to mediate satiety. Islet amyloid polypeptide (IAPP) is a recently discovered 37 amino acid peptide, mainly produced by the pancreatic ß-cells. READ MORE