Search for dissertations about: "islet transplantation and hypoxia"

Showing result 1 - 5 of 7 swedish dissertations containing the words islet transplantation and hypoxia.

  2. 1. Challenges in Islet Transplantation and Strategies to Improve Beta-Cell Function

    Author : Hanna Liljebäck; Per-Ola Carlsson; James Shaw; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet transplantation; Type 1 diabetes; Mesenchymal stem cells; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The incidence of type 1 diabetes is increasing worldwide and therapies of islet transplantation and potential cell-based therapies are rapidly evolving. Choosing the optimal site for such therapies is crucial for safety and for obtaining the best possible outcome. READ MORE

  4. 2. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass

    Author : Daniel Espes; Per-Ola Carlsson; Joey Lau; Mia Phillipson; Eelco de Koning; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet transplantation; Alternative implantation sites; Exendin-4; Positron Emission Tomography; 5-hydroxy tryptophan; Beta-cell mass; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. READ MORE

  5. 3. Exploring immune cell functions and ways to make use of them

    Author : Evelina Vågesjö; Mia Phillipson; Michael Hickey; Uppsala universitet; []
    Keywords : leukocytes; neutrophils; macrophages; regulatory T cells; chemokines; VEGF-A; hypoxia; ischemia; muscle; Islets of Langerhans; diabetes; transplantation; wound healing;

    Abstract : In addition to host defense, alternative functions of immune cells are emerging. Immune cells are crucial during healing of injured tissue, in formation of new blood vessels, angiogenesis, and also in maintaining the balance in inflammation having immune regulating functions. READ MORE

  6. 4. Functional characterization of pro-angiogenic neutrophils

    Author : Jalal Lomei; Mia Phillipson; Gustaf Christoffersson; Johan Kreuger; Lars Olaf Cardell; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; leukocytes; neutrophils; pro-angiogenic neutrophils; islets transplantation; intravital microscopy; aortic ring assay; phagocytosis; ROS production; hypoxia; vascular permeability; neutrophil recruitment; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The vascular system stretches throughout the body to provide oxygen, nutrition, and to remove waste products from cell metabolism. Angiogenesis, formation of new blood vessels by sprouting from pre-existing vessels, is one of the main mechanisms involved in blood vessel formation. READ MORE

  7. 5. In vivo imaging of islet cells and islet revascularization

    Author : Daniel Nyqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Glucose homeostasis depends on the release of insulin from the pancreatic beta-cell. Impaired insulin release is a hallmark of diabetes mellitus. READ MORE