Search for dissertations about: "islet transplantation and hypoxia"

Showing result 1 - 5 of 6 swedish dissertations containing the words islet transplantation and hypoxia.

  1. 1. Exploring immune cell functions and ways to make use of them

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Evelina Vågesjö; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leukocytes; neutrophils; macrophages; regulatory T cells; chemokines; VEGF-A; hypoxia; ischemia; muscle; Islets of Langerhans; diabetes; transplantation; wound healing;

    Abstract : In addition to host defense, alternative functions of immune cells are emerging. Immune cells are crucial during healing of injured tissue, in formation of new blood vessels, angiogenesis, and also in maintaining the balance in inflammation having immune regulating functions. READ MORE

  2. 2. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Daniel Espes; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet transplantation; Alternative implantation sites; Exendin-4; Positron Emission Tomography; 5-hydroxy tryptophan; Beta-cell mass; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. READ MORE

  3. 3. In vivo imaging of islet cells and islet revascularization

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine and Surgery

    Author : Daniel Nyqvist; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Glucose homeostasis depends on the release of insulin from the pancreatic beta-cell. Impaired insulin release is a hallmark of diabetes mellitus. READ MORE

  4. 4. Hypoxia-inducible factor-1 (HIF-1) in pancreatic cancer cell aggressiveness and therapeutic resistance and the potential role for pancreatic endocrine cells in islet transplantation

    University dissertation from Stockholm : Karolinska Institutet, Dept of Clinical Science, Intervention and Technology

    Author : Xiaohui Jia; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic functions in various tissues, including both normal and malignant. It is known that a heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) mainly mediates this critical adaptation. READ MORE

  5. 5. Functional characterization of pro-angiogenic neutrophils

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jalal Lomei; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; leukocytes; neutrophils; pro-angiogenic neutrophils; islets transplantation; intravital microscopy; aortic ring assay; phagocytosis; ROS production; hypoxia; vascular permeability; neutrophil recruitment; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The vascular system stretches throughout the body to provide oxygen, nutrition, and to remove waste products from cell metabolism. Angiogenesis, formation of new blood vessels by sprouting from pre-existing vessels, is one of the main mechanisms involved in blood vessel formation. READ MORE