Search for dissertations about: "j774"

Showing result 1 - 5 of 8 swedish dissertations containing the word j774.

  2. 1. Mechanisms of the intracellular survival of Francisella tularensis

    Author : Linda Tancred; Anders Sjöstedt; Jean Celli; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Igl; MglA; J774; IFN-γ; RNS; ROS; phagosome; Clinical bacteriology; Klinisk bakteriologi; mikrobiologi; Microbiology;

    Abstract : Francisella tularensis is a gram-negative, highly virulent, intracellular bacterium which causes the zoonotic disease tularemia. The subspecies tularensis and holarctica are clinically important, and the former is the more virulent. The intracellular lifestyle of F. READ MORE

  4. 2. Characterization of the attenuated Francisella tularensis strain FSC043 : with special focus on the gene pdpC

    Author : Marie Lindgren; Anders Sjöstedt; Marina Santic; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; intracellular bacteria; J774; apoptosis; pyroptosis; PdpC; FSC043; Clinical Bacteriology; klinisk bakteriologi; mikrobiologi; Microbiology;

    Abstract : Francisella tularensis is a highly infective, intracellular bacterium. It is capable of infecting a wide range of mammals and causes the disease tularemia in humans. As a result of its high infectivity there have been a lot of efforts made to create a generally available vaccine against this pathogen. READ MORE

  5. 3. TRAPC : a novel triggering receptor expressed on antigen presenting cells

    Author : Rutger van der Holst; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TREM; DAP12; Receptors; Signaling; Antigen presenting cells;

    Abstract : The triggering receptor expressed on myeloid cells (TREM) family of receptors plays an important role in innate immunity. They have been described to regulate the course of sepsis, DC maturation, bone modulation and microglial function, and as markers for bacterial infections. READ MORE

  6. 4. Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins

    Author : Markus Karlsson; Christina Frennesson; Sven Erik Nilsson; Tino Kurz; Ulf Brunk; Anders Kvanta; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Oxidative stress is a major pathogenic factor in the development of age-related macular degeneration (AMD), which is the most common cause of severe central visual impairment in the elderly population in the western world.It is believed that the degenerative process starts in the retinal pigment epithelium (RPE). READ MORE

  7. 5. The Lysosomal-Mitochondrial Axis Theory of Apoptosis

    Author : Ming Zhao; Sten Orrenius; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : In many cases, apoptosis may be initiated by a minor lysosomal destabilization, which some time later is followed by a secondary, more pronounced, lysosomal rupture. After exposure to low concentrations of sphingosine, a lysosomotropic detergent, Jurkat and J774 cells underwenr apoptotic cell death, while cells exposed to higher concentrations of this agent showed necrosis. READ MORE