Search for dissertations about: "jak-stat"

Showing result 6 - 10 of 36 swedish dissertations containing the word jak-stat.

  2. 6. Functional characterization of interactions between the flavivirus NS5 protein and PDZ proteins of the mammalian host

    Author : Karin Ellencrona; Magnus Johansson; Andrew Davidson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus TBEV ; West-Nile virus WNV ; Dengue virus DENV ; flavivirus; PDZ domains; ZO-2; ZO-1; RIMS2; Scribble; Interferon; JAK-STAT signaling; PDZ array; virus-host protein interaction; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Abstract : Flaviviruses are found all over the world and affect and infect millions of people every year. Flavivirus infection can lead to severe clinical outcomes resulting in neuronal damages e.g. Tick-borne encephalitis virus (TBEV), or severe hemorrhagic fevers e. READ MORE

  4. 7. Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection

    Author : Annelie Tjernlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : LIF; HIV-1; lymphoid tissue; cytokine; innate immune response; Jak Stat signalling pathway; cMAGI cells; siRNA;

    Abstract : Leukemia inhibitor factor (LIF) is a polyfunctional cytokine that belongs to the IL-6 family which mainly signals through the Jak/Stat pathway via the gp130/LIFR-α heterodimer. The focus of my research has been to investigate and understand if and how LIF exerts HIV1 suppressing activity. READ MORE

  5. 8. Drosophila skeletal muscles regulate the cellular immune response against wasp infection

    Author : Hairu Yang; Dan Hultmark; Tomas Dolezal; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Drosophila melanogaster is widely used as a model organism to study the innate immune system because it lacks an adaptive immune response that could mask its innate immune response. The innate immune response of Drosophila primarily consists of humoral and cellular immune responses. READ MORE

  6. 9. Gene regulation in psoriatic keratinocytes : microRNAs and cytokine responses

    Author : Ankit Srivastava; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Psoriasis is the most common chronic skin inflammation in adults which affects 2-4% of the world population. Keratinocytes are the key structural cells in epidermis which hyper-proliferate and undergo aberrant differentiation in psoriasis. READ MORE

  7. 10. Molecular and functional studies of the BCR/ABL1 fusion gene

    Author : Petra Johnels; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; onkologi; Cytologi; cancerology; oncology; Cytology; gene expression profiling; acute lymphoblastic leukemia; chronic myeloid leukemia; Ph chromosome; BCR ABL; extracellulära vätskor; Clinical genetics; Klinisk genetik; cancer;

    Abstract : The BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. READ MORE