Search for dissertations about: "johan bylund"

Found 5 swedish dissertations containing the words johan bylund.

  2. 1. Cytochrome P450 enzymes in oxygenation of prostaglandin endoperoxides and arachidonic acid : Cloning, expression and catalytic properties of CYP4F8 and CYP4F21

    Author : Johan Bylund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Cytochrome P450 (P450 or CYP) is an enzyme system involved in the oxygenation of a wide range of endogenous compounds as well as foreign chemicals and drugs. This thesis describes investigations of P450-catalyzed oxygenation of prostaglandins, linoleic and arachidoniacids. READ MORE

  4. 2. Recognition by leukocyte formyl peptide receptors. Promiscuous binding or pattern recognition?

    Author : Johan Bylund; Göteborgs universitet; []
    Keywords : neutrophils; chemoattractant; FPRL1; NADPH-oxidase; LPS; priming; subcellular organelles; human; murine;

    Abstract : Neutrophil granulocytes play an important role in the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they phagocytose microbes and cell debris from damaged host tissues. READ MORE

  5. 3. Traumatic brain injuries and whiplash injuries : epidemiology and long-term consequences

    Author : Johan Styrke; Britt-Marie Stålnacke; Ulf Björnstig; Peter Sojka; Per-Olof Bylund; David Cassidy; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic Brain Injuries; Whiplash Injuries; ; Epidemiology; ; Follow-up Studies; Cohort Studies; Epidemiology; epidemiologi; kirurgi; Surgery; rehabiliteringsmedicin; Rehabilitation Medicine;

    Abstract : BackgroundThe incidence of traumatic brain injuries (TBI) is about 500 cases per 100,000 inhabitants per year, a majority of which are mild TBI (MTBI). The incidence of whiplash injuries is about 300/100,000/year. READ MORE

  6. 4. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections

    Author : Berhane Asfaw Idosa; Eva Särndahl; Anne Kelly; Bo Söderquist; Alexander Persson; Johan Bylund; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteremia; Cytokines; Gene variants; Inflammasome; Inflammation; Innate immunity; Neutrophils; Meningitis; Neisseria meningitidis; Biomedicin; Biomedicine;

    Abstract : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. READ MORE

  7. 5. Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

    Author : Tomas Nilsson; Ernst Oliw; Johan Bylund; Mikael Hedeland; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epoxyalcohols; fatty acids; hydroperoxides; electrospray ionization; ichthyosis; CYP4; linear ion trap; fragmentation mechanism; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

    Abstract : Cytochrome P450 (CYP) family 4 constitutes monoxygenases responsible for hydroxylation of fatty acids and other lipids. For example, CYP4F3 metabolizes leukotrienes and CYP4F8 prostaglandin H. Importantly, six of the twelve CYP4 enzymes are orphans, i.e. READ MORE