Search for dissertations about: "kappa-b ligand"

Showing result 1 - 5 of 11 swedish dissertations containing the words kappa-b ligand.

  2. 1. Repression of transcription factor NF-[kappa]B by glucocorticoids : a molecular mechanism for their anti-inflammatory and immuno-modulatory effects

    Author : Johan Lidén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : It has been known since the late 1940s that glucocorticoids (GCs) possess anti-inflammatory activity. Their various uses in the clinic include treatment of, rheumatoid arthritis, asthma and AIM skin diseases and also as means for avoiding rejection during transplantation. READ MORE

  4. 2. Insights into the processes preceding the onset of rheumatoid arthritis

    Author : Linda Johansson; Solbritt Rantapää Dahlqvist; Mikael Brink; Felipe Andrade; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; pre-symptomatic individuals; autoantibodies; anti-citrullinated protein peptides antibodies; Epstein-barr virus; neutrophil extracellular traps; periodontitis; Porphyromonas gingivalis; receptor activator of nuclear factor kappa-B ligand; reumatologi; rheumatology;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by the production of anti-citrullinated protein antibodies (ACPA) in the majority of all patients and a persistent inflammation in the synovial tissue leading to joint destruction. The aetiology of RA remains to a large extent unknown but is believed to be a complex interplay between genetic, environmental and stochastic factors. READ MORE

  5. 3. Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations

    Author : Per Uhlén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Calcium; Ca2 signalling; Ca2 oscillation; InsP3; InsP3 receptor; Na; K-ATPase; ouabain; physical interaction; FRET; spectral analysis; confocal microscopy;

    Abstract : Signal transduction via ion fluxes is of vital importance for all mammalian cells. Cells can exploit ion regulatory mechanisms to generate and transmit intracellular signals. Improvements in digital microscopic imaging technology have made it possible to explore micro-environments and complex intracellular machineries. READ MORE

  6. 4. Chemokines and bone : lessons from in vitro and in vivo studies

    Author : Sara Rosendahl; Pernilla Lundberg; Cecilia Koskinen Holm; Elin Kindstedt; Marie Lagerquist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Bone homeostasis is maintained by the balanced activity of bone-forming osteoblasts and bone-resorbing osteoclasts. Inflammation in the vicinity of bone disturbs the balanced bone remodeling process, which often results in bone loss. READ MORE

  7. 5. Regulation of mucosal inflammation by fibroblasts

    Author : Tanya (De L.) Karlson; Göteborgs universitet; []
    Keywords : inflammatory bowel diseases; fibroblasts; CD40; C-EBPbeta; apoptosis; TGF-beta;

    Abstract : ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly followed by wound healing and resolution. However, in some individuals these mechanisms are not effective and the inflammatory bowel diseases, Crohn?s disease and ulcerative colitis result. READ MORE