Search for dissertations about: "keratin"

Showing result 1 - 5 of 27 swedish dissertations containing the word keratin.

  1. 1. Disease-causing Keratin Mutations and Cytoskeletal Dysfunction in Human Skin : In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses

    Author : Jean Christopher Chamcheu; Anders Vahlquist; Hans Törmä; Harshad Navsaria; Marie Virtanen; Torbjörn Egelrud; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidermolysis bullosa simplex; epidermolytic ichthyosis; genodermatoses; keratin; keratin mutation; keratinocytes; gene therapy; pharmacological therapy; immortalization; gene regulation; trimethylamine N-oxide TMAO ; sodium 4-phenylbutyrate 4-PBA ; tissue engineering; cell culture; heat shock proteins; MAP kinases; Dermatology and venerology; Dermatologi och venerologi; Dermatologi och venereologi; Dermatology and Venerology;

    Abstract : Epidermolysis bullosa simplex (EBS) and epidermolytic ichthyosis (EI) are rare skin fragility diseases characterized by intra-epidermal blistering due to autosomal dominant-negative mutations in basal (KRT5 or KRT14) and suprabasal (KRT1 or KRT10) keratin genes,  respectively. Despite vast knowledge in the disease pathogenesis, the pathomechanisms are not fully understood, and no effective remedies exist. READ MORE

  2. 2. On keratin mutations in epidermolytic hyperkeratosis and the regulation of keratin expression by retinoids

    Author : Marie Virtanen; Uppsala universitet; []
    Keywords : Medical sciences; EHK; keratin; retinoids; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Abstract : Epidermolytic hyperkeratosis is a rare inherited disease of the skin caused by a dominant-negative mutation in keratin 1 (K1) or 10 (K10). Keratins are the major structural protein in epidermis and mutations causes instability of intermediate filament and keratinocyte fragility. READ MORE

  3. 3. Bioprocessing of Recalcitrant Substrates for Biogas Production

    Author : Maryam M Kabir; Högskolan i Borås; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; anaerobic digestion; biogas; lignocellulose; wool; keratin; pre-treatment; co-digestion; dry digestion; economic evaluation; Resursåtervinning; Resource Recovery;

    Abstract : The application of anaerobic digestion (AD) as a sustainable waste management technology is growing worldwide, due to high energy prices as well as increasingly strict environmental regulations. The growth of the AD industry necessitates exploring new substrates for their utilisation in AD processes. READ MORE

  4. 4. Construction, expression and evaluation of anti-keratin 8 single-chain antibody fragments

    Author : Rozbeh Jafari; Birgitta Sundström; Jörgen Carlsson; Karlstads universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single-chain antibody fragments; keratin 8; site-directed mutagenesis; heterologous expression; P. pastoris; design of experiments; multicellular tumor spheroids; immunotargeting; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Antibodies are glycoproteins specifically binding to a variety of antigens and today extensively used in prevention, diagnosis and treatment of diseases. Carcinomas originate from epithelial tissues and are the most common forms of human malignancies. In the necrotic areas of carcinomas significant amounts of keratins (K) are found extracellularly. READ MORE

  5. 5. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems

    Author : Quoc Dat Pham; Fysikalisk kemi; []
    Keywords : stratum corneum; lipid; keratin filament; protein; DMPC; penetration enhancer; osmolyte; solvent; monoterpene; fatty acid; hydration; molecular mobility; fluidity; permeability; PT ssNMR; diffusion cell;

    Abstract : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. READ MORE