Search for dissertations about: "keratins"
Showing result 1 - 5 of 10 swedish dissertations containing the word keratins.
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1. In vitro Studies of Genodermatoses Affecting Cytoskeletal Integrity and Lipid Processing in Human Epidermis : Pathogenic Mechanisms and Effects of Retinoid Therapy
Abstract : Autosomal dominant epidermolytic ichthyosis (EI) is a rare disease characterized by intra-epidermal blistering due to mutations in either of two keratin genes, KRT1 and KRT10, expressed by suprabasal keratinocytes. Autosomal recessive congenital ichthyosis (ARCI) is a non-blistering, hyperkeratotic disease caused by mutations in one of the following genes: ABCA12, ALOX12B, ALOXE3, TGM1, CYP4F22, NIPAL4 and SLC27A4, which are all essential for skin barrier homeostasis. READ MORE
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2. Modeling of multi-step oral carcinogenesis in vitro : assessment of growth, differentiation and apoptosis markers
Abstract : Human oral mucosa, especially the buccal epithelium, is worldwide a common site for cancer. Cancer development frequently results in inactivation of tumor suppressor p53, a central regulator of growth and programmed cell death, and deregulated expression of structural elements like cytokeratins. READ MORE
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3. p63 and potential p63 targets in squamous cell carcinoma of the head and neck
Abstract : Squamous cell carcinoma of the head and neck (SCCHN), the 6th most common cancer worldwide, has a low 5-year survival. Disease as well as treatment often causes patients severe functional and aesthetic problems. READ MORE
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4. On keratin mutations in epidermolytic hyperkeratosis and the regulation of keratin expression by retinoids
Abstract : Epidermolytic hyperkeratosis is a rare inherited disease of the skin caused by a dominant-negative mutation in keratin 1 (K1) or 10 (K10). Keratins are the major structural protein in epidermis and mutations causes instability of intermediate filament and keratinocyte fragility. READ MORE
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5. New insights in contact allergy and drug delivery. A study of formulation effects and hapten targets in skin using two-photon fluorescence microscopy
Abstract : The skin is a remarkable barrier, protecting us from invasion of e.g. harmful microorganisms and UV-radiation. However, the skin is not adopted to resist repeated exposure to the multitude of xenobiotics introduced into modern society. READ MORE