Search for dissertations about: "kinase design"
Showing result 1 - 5 of 33 swedish dissertations containing the words kinase design.
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1. Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors
Abstract : Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong association with diseases, details of their physiologic and pathologic mechanisms remain at least partially unclear, especially the spatiotemporal dynamics of the signalling. READ MORE
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2. Design and Synthesis of Chalcone and Chromone Derivatives as Novel Anticancer Agents
Abstract : This thesis comprises the design and synthesis of chalcone and chromone derivatives and their use in various biological applications, particularly as anticancer agents (targeting proteins associated with cancer pathogenesis) and as potential fluorophores for live-cell imaging. Conveniently, all structures presented were synthesized from commercially available 2 ́-hydroxyacetophenones. READ MORE
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3. The cyanobacterial pigments scytonemin and nostodione A - Synthesis, photophysicochemical behavior and biological studies
Abstract : The natural UV-screener scytonemin is found in a plethora of cyanobacterial species. Its UV-protective ability allows the bacteria to thrive in inhospitable locations exposed to intense solar radiation. Scytonemin has a dimeric structure consisting of two 1-1' linked 3-(4-hydroxybenzylidene)cyclopenta[b]indole-2-one moieties. READ MORE
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4. Computer-aided drug design approaches in developing anti-cancer inhibitors
Abstract : The thesis entitled “computer-aided drug design approaches in developing anti-cancer drug” is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. READ MORE
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5. Free-energy studies of ligand-binding affinities
Abstract : In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. We have assessed and used computational tools for this aim, most of them based on molecular dynamics (MD) simulations. READ MORE