Search for dissertations about: "kinase"

Showing result 11 - 15 of 1297 swedish dissertations containing the word kinase.

  2. 11. Crystallographic studies of gluconate kinase

    Author : Louise Kraft; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The first steps of gluconate metabolism in Escherichia coli are the transport of gluconate into the cell by a gluconate transport system, followed by phosphorylation to gluconate-6- phosphate by gluconate kinase. There exist two such different pathways, Grill and GntIl, respectively. READ MORE

  4. 12. Protein Kinase Inhibition in Late Cerebral Ischemia after Subarachnoid Hemorrhage

    Author : Saema Ansar; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; protein kinase; cerebral ischemia; subarachnoid hemorrage; neurofysiologi; neuropsykologi;

    Abstract : The cerebral ischemia that occur after a subarachnoid hemorrhage (SAH) often results in death or severe disability and is a significant cause of stroke. Our hypothesis is that cerebral ischemia leads to pathophysiological receptor changes on the vascular smooth muscle cells. READ MORE

  5. 13. Studies of PDGF receptor signaling in vitro and in vivo

    Author : Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

    Abstract : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. READ MORE

  6. 14. Deoxyribonucleoside kinases in bacteria, plants and humans

    Author : Anders Ranegaard Clausen; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; anti-viral drugs; gene therapy; cancer; evolution; nucleoside analog; deoxyribonucleoside kinase; thymidine kinase;

    Abstract : Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA and can be synthesized either de novo or via salvage pathways. The first reaction in the salvage pathway of dNTPs is the conversion of deoxyribonucleosides (dN) into the deoxyribonucleoside monophosphate (dNMP). READ MORE

  7. 15. Structure-Function Studies of Enzymes from Ribose Metabolism

    Author : C. Evalena Andersson; Sherry Mowbray; Phil Evans; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; activation; isomerase; kinase; potassium; product inhibition; ribose; ribose 5-phosphate; x-ray crystallography; enzyme kinetics; fluorescence spectroscopy; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : In the pentose phosphate pathway, carbohydrates such as glucose and ribose are degraded with production of reductive power and energy. Another important function is to produce essential pentoses, such as ribose 5-phosphate, which later can be used in biosynthesis of nucleic acids and cofactors. READ MORE