Search for dissertations about: "kinases"

Showing result 16 - 20 of 363 swedish dissertations containing the word kinases.

  2. 16. Regulation and Function of MAP Kinases in PDGF Signaling

    Author : Glenda Eger; Johan Lennartsson; Carl-Henrik Heldin; Martin Gullberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; MAP kinase; Erk1 2; Erk5; Dusp MKP; NR4A1; cancer; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. READ MORE

  4. 17. Substrate specificity of protein kinases studied with synthetic peptides

    Author : Reet Toomik; Uppsala universitet; []
    Keywords : Medical sciences; protein kinase A; protein kinase C; substrate; peptide; specificity; stereospecificity; assay; SPOTS peptides; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : This thesis concentrates on the substrate specificities of protein kinases A and C (PKA, PKC). Synthetic peptides are used for that purpose, both in soluble and cellulose membrane-bound form. The, stereospecificity of both protein kinases was studied with D-amino acid containing synthetic peptides. READ MORE

  5. 18. Protein Tyrosine Phosphatases as Regulators of Receptor Ryrosine Kinases

    Author : Camilla Persson; Arne Östman; Niels Peter Moller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; protein tyrosine phosphatase; tyrosine kinase; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Tyrosine phosphorylation is a crucial mechanism in cellular signaling and regulates proliferation, differentiation, migration and adhesion. The phosphorylation reaction is reversible and is governed by two families of enzymes: protein tyrosine kinases and protein tyrosine phosphatases (PTPs). READ MORE

  6. 19. Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases

    Author : Fredrik Lennmyr; Andreas Terént; Tommy Olsson; Uppsala universitet; []
    Keywords : Medical sciences; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : Cerebral ischemia elicits a wide range of events, including complex activation of various intracellular signaling pathways. This study aims to investigate the expression of vascular endothelial growth factor (VEGF) and the activation pattern of mitogen-activated protein kinases (MAPK) in reponse to focal cerebral ischemia. READ MORE

  7. 20. The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

    Author : Zeeshan Mutahir; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc. READ MORE