Search for dissertations about: "kinetic isotope effect"

Showing result 1 - 5 of 18 swedish dissertations containing the words kinetic isotope effect.

2. 1. Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects

   Author : Susanna MacMillar; Olle Matsson; Anita Hussénius; Daniel M. Quinn; Uppsala universitet; []
   Keywords : Organic chemistry; nucleophilic bimolecular substitution SN2; kinetic isotope effects; precision conductometry; monoamine oxidase B MAO B; reaction mechanism; carbon 11C 14C kinetic isotope effect; ion pairing triple-ion formation; para-substituted benzyl chlorides; tetrabytylammonium cyanide; Organisk kemi;

   Abstract : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. READ MORE

4. 2. Multiple Kinetic Isotope Effect Study of an Elimination Reaction

   Author : Per Ryberg; Uppsala universitet; []
   Keywords : ;

   Abstract : .... READ MORE

5. 3. Concerted or Stepwise? : β-Elimination, Nucleophilic Substitution, Copper Catalysed Aziridination and Ruthenium Catalysed Transfer Hydrogenation Studied by Kinetic Isotope Effects and Linear Free-Energy Relationships

   Author : Per Ryberg; Heinz F. Koch; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Kinetic isotope effect; linear free energy relationship; elimination; substitution; aziridination; transfer hydrogenation; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : This thesis describes the use of kinetic isotope effects, linear free energy relationships and stereochamical studies to distinguish between different mechanistic alternatives and to obtain information about transition state structure.In the first part fluorine and deuterium kinetic isotope effects were determined for the base promoted HF elimination from 4-fluoro-4-(4’-nitrophenyl)butane-2-on. READ MORE

6. 4. Volume kinetic development and application

   Author : Dan Drobin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Fluid therapy is a cornerstone in shock resuscitation in a such as treatment of anesthesia induce down regulation of the circulation and also restores many different types of dehydrated states. Current guidelines for fluid therapy are, however, based on experience, rules of thumb and effect-related end points, such as restoration of physiological parameters, which do not directly represent the volume effect of the fluid. READ MORE

7. 5. Proton, Electron, and O2 transfer in Cytochrome c Oxidase

   Author : Lina Salomonsson; Peter Brzezinski; Marilyn Gunner; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; electron transfer; proton transfer; proton pumping; kinetic isotope effect; Biochemistry; Biokemi;

   Abstract : In mitochondria and aerobic bacteria energy conservation involves electron transfer through the membrane-bound protein of the respiratory chain to oxygen. Cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water. Part of the energy released in this reaction is used to pump protons across the membrane. READ MORE