Search for dissertations about: "kinetic resolution"

Showing result 6 - 10 of 123 swedish dissertations containing the words kinetic resolution.

2. 6. Heterogeneous catalysis in racemization and kinetic resolution along a journey in protein engineering

   Author : Tamás Görbe; Jan-Erling Bäckvall; Frank Hollmann; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; racemization; protein engineering; kinetic resolution; heterogeneous catalysis; biohybrid catalyst; organisk kemi; Organic Chemistry;

   Abstract : The first part of my thesis concerns the use of heterogeneous acidic resins for racemization of tert-alcohols without any side-product formation. The focus was to develop a system which can be further extended to a DKR protocol consisting of an enzymatic KR reaction. READ MORE

4. 7. Dynamic Systems : Enzymatic Synthesis, Exchange Reactions and Applications in Materials Science

   Author : Yang Zhang; Olof Ramström; Mihail D. Barboiu; KTH; []
   Keywords : constitutional dynamic chemistry; reversible reactions; kinetic resolution; dynamic kinetic resolution; enzyme catalysis; lipase; asymmetric synthesis; racemization; oxazolidinone; organogel; enamine; nitroaldol reaction.;

   Abstract : This thesis is divided into three parts, revolving around the developments of dynamic systems utilized in dynamic kinetic resolution (DKR) and constitutional dynamic chemistry (CDC).The first section gives an introduction to constitutional dynamics, the core concept of this thesis. READ MORE

5. 8. Surface Plasmon Resonance : Sensitivity and Resolution

   Author : Knut Johansen; Günter Gauglitz; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Surface plasmon resonance (SPR) is a frequently used technique for detection of biomolecular interactions at surfaces. The SPR phenomenon emanates from an electromagnetic surface wave that is exited by a light source. READ MORE

6. 9. Enantioselective biotransformations using engineered lipases from Candida antarctica

   Author : Karin Engström; Jan-E. Bäckvall; Manfred T. Reetz; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein engineering; directed evolution; kinetic resolution; dynamic kinetic resolution; biotransformation; lipase; organisk kemi; Organic Chemistry;

   Abstract : Enzymes are attractive catalysts in organic synthesis since they are efficient, selective and environmentally friendly. A large number of enzyme-catalyzed transformations have been described in the literature. READ MORE

7. 10. Synthetic Transformations via Metal- and Enzyme-Catalyzed Dynamic Kinetic Resolution

   Author : Krisztián Bogár; Jan-Erling Bäckvall; Romas Kazlauskas; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ruthenium; racemization; lipase; dynamic kinetic resolution; secondary alcohol; Candida antarctica lipase B; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Abstract : This thesis deals with the preparation of a new half-sandwich type ruthenium(II)- catalyst for racemization of optically active secondary alcohols and the development of a highly efficient method in combination with lipases such as Candida antarctica lipase B and Pseudomonas cepacia lipase for dynamic kinetic resolution of various functionalized alcohols under mild reaction conditions.It was shown that the RuCl(CO)2(η5-C5Ph5) complex can racemize optically active aliphatic and aromatic secondary alcohols at room temperature in rather short times. READ MORE