Search for dissertations about: "kinetochore nuclear atypia anaphase bridge p53 breakage-fusion-bridge cycle TP53 HMGIC MDM2 mitotic instability genomic instability FISH osteosarcoma liposarcoma amplification tumour chromosome cytogenetics Clinical genetics Klinisk genetik"

Found 1 swedish dissertation containing the words kinetochore nuclear atypia anaphase bridge p53 breakage-fusion-bridge cycle TP53 HMGIC MDM2 mitotic instability genomic instability FISH osteosarcoma liposarcoma amplification tumour chromosome cytogenetics Clinical genetics Klinisk genetik.

2. 1. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

   Author : David Gisselsson Nord; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

   Abstract : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. READ MORE