Search for dissertations about: "knock-out mouse"

Showing result 16 - 20 of 57 swedish dissertations containing the words knock-out mouse.

  2. 16. Physiology and pathophysiology of central adenosine A1 and A2A receptors

    Author : Linda Halldner Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine; A1 receptor; A2A receptor; knock-out mouse; in situ hybridization; receptor autoradiography; sleep; hypoxia-ischemia; behavior; motor activity; caffeine; tolerance;

    Abstract : The aim of this thesis was to further investigate the individual roles of central adenosine A1 and A2A receptors in the physiological and pathophysiological effects of adenosine. In addition, the characteristics of different adenosine receptor ligands were studied. READ MORE

  4. 17. Regulation and function of the Clara cell secretory protein

    Author : Magnus Nord; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung Clara cells Uteroglobin Polychlorinated biphenyls Rat Mouse Hu-man Fetal development Glucocorticoids Cells; cultured Gene expression regulation CEBP Calcium Protein conformation Computer simulation Mutagenesis; site-directedCalcium binding pr;

    Abstract : The Clara cell secretory protein (CCSP; also known as Polychlorinated Biphenyl-binding protein (PCB-BP) or Uteroglobin) is specifically produced and secreted into the distal airway lumen by the non-ciliated Clara cell. It is a low molecular weight homodimeric protein and binds certain metabolites of PCBs as well as progestins and calcium. READ MORE

  5. 18. Identification and investigations of leucine-rich repeats and immunoglobulin-like domains protein 2 (LRIG2)

    Author : Camilla Holmlund; Håkan Hedman; Roger Henriksson; Monica Nistér; Umeå universitet; []
    Keywords : LRIG; PDGF; oligodendroglioma; MEDICINE; MEDICIN; onkologi; Oncology;

    Abstract : Receptor tyrosine kinases (RTKs) constitute a family of proteins controlling cell growth and proliferation and whose activities are tightly controlled in normal cells. LRIG1 is a negative regulator of RTK signaling and is a proposed tumor suppressor. The aim of this thesis was to identify and study possible paralogs of LRIG1. READ MORE

  6. 19. The role of FPR2/ALX in the vascular wall

    Author : Marcelo Petri; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet Dept. of Medicine; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cardiovascular diseases caused by atherosclerosis are a leading cause of mortality worldwide. Inflammation has been described as a key component in the development of atherosclerosis. Lipoxin A4 (LXA4) is a lipid mediator derived from arachidonic acid, which has anti-inflammatory and pro-resolution properties mediated through the FPR2/ALX receptor. READ MORE

  7. 20. Epigenetic Mapping in Type 2 Diabetes. Glucose-triggered histone modifications in various tissues

    Author : Bompada Pradeep; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; epigenetics; histone modifications; genome editing; ChIP-seq; RNA-seq; pancreatic islets; diabetic kidney disease; peripheral blood mononuclear cells; atherosclerosis;

    Abstract : Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. READ MORE