Search for dissertations about: "knockout mouse"

Showing result 1 - 5 of 198 swedish dissertations containing the words knockout mouse.

  2. 1. The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse

    Author : Frida A. Lindberg; Robert Fredriksson; Erika Roman; Karin Nordenankar; Vootele Vöikar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Solute carrier; SLC; SNAT10; SLC38A10; phenotyping; behavior; amino acids; knockout mouse model; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. READ MORE

  4. 2. The Role of the SHB Adapter Protein in Cell Differentiation and Development

    Author : Vitezslav Kriz; Michael Welsh; Urban Lendahl; Uppsala universitet; []
    Keywords : Cell biology; SHB; transgene; ES cells; cavitation; knockout; mouse; vasculogenesis; hematopoiesis; endoderm; mesoderm; malformation; Cellbiologi;

    Abstract : The present study was conducted in order to assess a role of the SH2 domain-containing adapter protein SHB in development and cell differentiation.Embryonic stem (ES) cells overexpressing SHB and SHB with an inactive SH2 domain (R522K-SHB) were obtained. READ MORE

  5. 3. Feedback Enhancement of Antibody Responses via Complement and Fc Receptors

    Author : Jörgen Dahlström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; complement; IgG; IgM; IgE; Fc-gamma-RI; Fc-gamma-RII; Fc-gamma-RIII; CR1; CR2; CD21; CD35; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for IgG (FcγRI, FcγRII and FcγRIII) and complement receptors 1 and 2 (CR1/2) for antibody-mediated enhancement of antibody responses are investigated. READ MORE

  6. 4. Fcγ Receptors in the Immune Response

    Author : Teresita Díaz de Ståhl; Jan van de Winkel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Fc Receptors; IgG Receptors; IgE Receptors; Immune regulation; In vivo animal models; Mouse; Rh prophylaxis; Rheumatoid arthritis; Transgenic knockout; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Circulating immune complexes play an important role in the modulation of antibody responses and in the pathogenesis of immune diseases. This thesis deals with the in vivo regulatory properties of antibodies and their specific Fc receptors. READ MORE

  7. 5. Functions of platelet-derived growth factor-A during organogenesis

    Author : Linda Karlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor-A; knockout; mouse organogenesis; epithelial-mesenchymalinteractions; skin; hair follicles; CNS; lung; gastrointestinal villus;

    Abstract : The formation of organs during embryonic development is calledorganogenesis. This process is regulated by the genes residing in the genome. READ MORE