Search for dissertations about: "knockout"

Showing result 1 - 5 of 385 swedish dissertations containing the word knockout.

2. 1. The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse

   Author : Frida A. Lindberg; Robert Fredriksson; Erika Roman; Karin Nordenankar; Vootele Vöikar; Uppsala universitet; []
   Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC; SNAT10; SLC38A10; phenotyping; behavior; amino acids; knockout mouse model; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. READ MORE

4. 2. The Role of Hox Transcription Factors in the Regulation of Hematopoiesis

   Author : Mattias Magnusson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; Haematology; Hox genes; Knockout; Hematopoietic stem cells; Hematopoiesis; Transcription Factor;

   Abstract : Hematopoiesis is a lifelong, dynamic process, originating from a low number of hematopoietic stem cells (HSCs) residing in the adult bone marrow with the ability to self-renew and generate all blood lineages throughout life. Recent findings have demonstrated that the Homeobox (Hox) transcription factors are important regulators of both normal and malignant hematopoiesis, controlling proliferation, differentiation and self-renewal of hematopoietic cells at different levels of the hematopoietic hierarchy. READ MORE

5. 3. Factors Contributing to Detrusor Overactivity - Obstruction, Hypertrophy and Afferent Nerve Stimulation

   Author : Annette Schröder; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; knockout; mice; estrogen receptor; EP1 receptor; prostaglandin; rat; endothelin; detrusor overactivity; rabbit; smooth muscle; bladder outlet obstruction; hypertrophy; pharmacognosy;

   Abstract : The consequences of bladder outlet obstruction (BOO) with respect to detrusor hypertrophy, structural and functional changes, and obstruction-induced detrusor overactivity were investigated in vivo and in vitro utilizing various animal models. Possible pathophysiological pathways and therapeutic approaches were tested by drug treatment and the use of knockout models. READ MORE

6. 4. The role of TGF-§ in hematopoiesis

   Author : Jonas Larsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transforming growth factor-§; Cre loxP system; receptor; knockout; embryogenesis; angiogenesis; hematopoiesis; hematopoietic stem cell; inflammation; Medicine human and vertebrates ; Medicin människa och djur ;

   Abstract : Transforming growth factor-§ (TGF-§) is a potent, multifunctional growth factor affecting virtually all cell types, regulating critical physiological processes like immune response, wound healing, angiogenesis, and tumor development. A large number of studies in vitro have also implicated a critical role of TGF-§ in regulating hematopoiesis by inhibiting proliferation of hematopoietic stem cells (HSCs). READ MORE

7. 5. Investigating the function of Anaplastic Lymphoma Kinase

   Author : Emma Vernersson Lindahl; Bengt Hallberg; Ruth Palmer; Göran Roos; Carina Hellberg; Umeå universitet; []
   Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALK; nervous system; knockout; development; Jelly-Belly; Pathology; Patologi;

   Abstract : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. READ MORE