Search for dissertations about: "koskiniemi"

Found 5 swedish dissertations containing the word koskiniemi.

2. 1. Enzymatic activation of oxygen in the biosynthesis of polyketide antibiotics

   Author : Hanna Koskiniemi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The electron structure of molecular oxygen (O2) is such that it cannot spontaneously react with organic molecules, a feature that protects organisms from oxidative stress. However, oxygenases can insert O2 in organic substrates. The enzymes do this after activating O2 for the reaction, most often with the aid of an organic or inorganic cofactor. READ MORE

4. 2. Dynamics of the Bacterial Genome : Rates and Mechanisms of Mutation

   Author : Sanna Koskiniemi; Dan Andersson; Diarmaid Hughes; Ivan Matic; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteria; bacterial evolution; genome reduction; gene loss; serial passage; DNA homology; tranlesion DNA polymerase; stress; Microbiology; Mikrobiologi; Bacteriology; Bakteriologi; Evolutionary Genetics; Evolutionär genetik; Mikrobiologi; Microbiology;

   Abstract : Bacterial chromosomes are highly dynamic, continuously changing with respect to gene content and size via a number of processes, including deletions that result in gene loss. How deletions form and at what rates has been the focus of this thesis. In paper II we investigated how chromosomal location affects chromosomal deletion rates in S. READ MORE

5. 3. To defend or to offend? : Bacterial defence and competition systems

   Author : Danna Lee; Sanna Koskiniemi; Marjan van der Woude; Uppsala universitet; []
   Keywords : bacterial defence systems; bacterial competition systems; toxin-antitoxin systems; colicin; contact-dependent growth inhibition CDI ; type VI secretion system T6SS ; Rearrangement hotspot Rhs proteins; CRISPR; horizontal gene transfer; antibiotic resistance; Salmonella; Enterotoxigenic E. coli ETEC ; probiotics; synthetic biology.;

   Abstract : Bacteria are prokaryotic microorganisms that can be found in all niches of the biosphere. Bacteria must constantly evolve in order to survive and adapt to their environments. Defence systems and competition systems play a vital role in ensuring the survival of bacteria. READ MORE

6. 4. The effects of internally expressed Contact-Dependent growth Inhibition (CDI) toxins in bacteria

   Author : Magnus Stårsta; Sanna Koskiniemi; Pierre Genevaux; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Bacteria, both pathogenic and non-pathogenic, have developed multiple forms of competition mechanisms to combat each other including, but not limited to, Contact-Dependent growth Inhibition (CDI) systems, Type VI Secretion Systems and the associated Rearrangement hotspot (Rhs) toxin system. These systems usually confers a great fitness advantage as they allow for precise delivery of toxic molecules into competing bacteria whilst sister cells are protected from auto-inhibition by producing a cognate immunity protein. READ MORE

7. 5. Too close for comfort : The role of Contact-Dependent growth Inhibition (CDI) in interbacterial competition and cooperation

   Author : Marcus Wäneskog; Sanna Koskiniemi; Paul Rainey; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bacterial interactions; cell-cell binding; contact-dependent growth inhibition; CDI; CdiB; CdiA; CdiI; outer-membrane receptor; BamA; OmpC; OmpF; extracellular toxin delivery; Toxin-Antitoxin; TA-system; persister cells; stress tolerance; stress response; rpoS; rssB; quorum sensing; multicellular behavior; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Abstract : Contact-Dependent growth inhibition (CDI) was discovered in 2005 in the E. coli isolate EC93. Since then our knowledge of CDI systems and their impact on bacterial communities have increased exponentially. READ MORE