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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.

  2. 1. Mitochondrial Energy Metabolism : Kgd4 is a novel subunit of the α-ketoglutarate dehydrogenase complex

    Author : Manfred Heublein; Martin Ott; Flavia Fontanesi; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; α-ketoglutarate dehydrogenase; Kgd4; Krebs cycle; Biochemistry; biokemi;

    Abstract : Mitochondria are essential organelles of eukaryotic cells and are responsible for their energy metabolism. The citric acid cycle, a chain of redox reactions in the mitochondrial matrix, is a central metabolic hub. READ MORE

  4. 2. Prostate Cancer Diagnosis : experimental and Clinical Studies With HRMAS NMR Spectroscopy

    Author : Katarina Stenman; Katrine Åhlström-Riklund; Anders Bergh; Peter Lundberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; PCa; HRMAS NMR; MRSI; metabolomics; Gleason score; citrate; inositol; choline; Krebs cycle; PUFA; omega-6; omega-3; Diagnostic radiology; Diagnostisk radiologi; Radiology; radiologi;

    Abstract : A few abnormal cells found in a small piece of prostate tissue are most consequential for a man’s future. The prevalence of prostate cancer (PCa) is increasing globally. READ MORE

  5. 3. Metabolomics and flux analysis by mass spectrometry : Investigations of factors associated with insulin secretion and prostate cancer risk

    Author : Johnny Östman; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Two of the most common diseases associated with the Western lifestyle are type 2 diabetes (T2D) and prostate cancer (PCa). This is in large part due to decreased physical activity, surplus of dietary energy, and an ageing population. READ MORE

  6. 4. Metabolic intervention during blood cardioplegia. Clinical studies in coronary surgery and heart transplantation

    Author : Ulf Kjellman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac surgery; heart transplantation; oxygen extraction; substrate metabolism; predictors of ischemic injuries; a - ketoglutarate; insulin;

    Abstract : Myocardial ischemia and injury (infarction) during open heart surgery and heart transplantation is a problem in spite of the fact that it is a safe procedure today. The myocardial substrate metabolism is well investigated before and after the cardioplegic period but little knowledge exists about the myocardial metabolic changes during cardioplegia. READ MORE

  7. 5. Protein phosphorylation cascades regulating islet beta-cell insulin exocytosis through glucose sensing and drug signaling : with special focus on serine/threonine protein phosphates and hypoglycemic sulfonylureas

    Author : Mikael Lehtihet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Diabetes; Islet; Insulin; Exocytosis; Protein phosphatase; Protein kinase; CPT-1; Sulfonylurea; Glutamate; Polyphosphoinositide;

    Abstract : In human type 2 diabetes, loss of glucose-sensitive insulin secretion from the pancreatic �-cell is an early pathogenetic event. Initially, this may be compensated for by stimulating insulin secretion by sulfonylurea drugs. READ MORE