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Showing result 1 - 5 of 663 swedish dissertations matching the above criteria.

2. 1. Selective serotonin re-uptake inhibitors in the environment : Effects of citalopram on fish behaviour

   Author : Martin Kellner; Håkan Olsén; Inger Porsch-Hällström; Magnus Breitholtz; Södertörns högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Citalopram; SSRI; stickleback; Baltic; behaviour; fish; feeding; anxiety; boldness; serotonin; development; Storspigg; serotonin; östersjön; SSRI; läkemedel; miljö; citalopram; ätbeteende; beteende; utveckling; Environmental Studies; Miljövetenskapliga studier; Östersjö- och Östeuropaforskning; Baltic and East European studies;

   Abstract : Selective serotonin re-uptake inhibitors (SSRIs) are a class of anxiolytic and anti-depressant drugs. SSRIs act on the evolutionarily ancient serotonergic system which is virtually identical throughout the vertebrate phylum. READ MORE

4. 2. Tamiflu® - Use It and Lose It?

   Author : Josef D. Järhult; Björn Olsen; Hanna Söderström; Jonas Waldenström; Robert G. Webster; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; oseltamivir; Tamiflu; resistance development; H274Y; environment; pharmaceuticals; mallard; dabbling duck; avian influenza; influensa; resistensutveckling; miljö; läkemedel; gräsand; Infektionssjukdomar; Infectious Diseases;

   Abstract : Influenza A viruses cause seasonal and pandemic outbreaks that range from mild infections to the disastrous Spanish Flu. Resistance to neuraminidase inhibitors (NAIs) is a growing problem as these drugs constitute a vital part of treatment strategies and pandemic preparedness plans worldwide. Oseltamivir (Tamiflu®) is the mostly used NAI. READ MORE

5. 3. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?

   Author : Sandra Holt; Christopher J Fowler; Anders Bucht; Gunnar Tiger; Ruth A Ross; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; FAAH; anandamide; endocannabinoid; pH; inflammation; NSAID; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

   Abstract : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. READ MORE

6. 4. "Under pressure" : interaction between pharmaceuticals and river bacteria

   Author : Aleksandra Hagberg; Madeleine Ramstedt; Mette Burmølle; Jerker Fick; Rikke Louise Meyer; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biofilms; river bacteria; pharmaceutical contamination;

   Abstract : Pharmaceuticals are often entering the environment without being completely decomposed. Once released in the environment they continue to carry on their main function but instead targeting the inhabitants of the aquatic ecosystem. Our interest was drawn towards the bacteria, that are often present in the environment in the form of biofilms. READ MORE

7. 5. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase

   Author : Cecilia Lindgren; Anna Linusson; Antti Poso; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; class II MHC protein; drug design; molecular dynamics simulation; multicomponent system; nerve agent; oxime; quantitative structure-activity relationship; reactivator; rheumatoid arthritis; statistical molecular design; T-cell receptor;

   Abstract : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. READ MORE