Search for dissertations about: "läkemedelskemi"

Showing result 1 - 5 of 203 swedish dissertations containing the word läkemedelskemi.

  1. 1. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hanna Andersson; Anders Hallberg; Anders Karlén; Federico Corelli; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin IV; AT4; insulin-regulated aminopeptidase IRAP ; inhibitor; peptidomimetics; γ-turn mimetic; macrocycle; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. READ MORE

  2. 2. Hit Identification and Hit Expansion in Antituberculosis Drug Discovery Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anneli Nordqvist; Anders Karlén; Mats Larhed; Anders Hallberg; Anna Linusson; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; Glutamine synthetase; Imidazo[1; 2-a]pyridine analogues; Focused hierarchical design of experiments; DXR; Fosmidomycin analogues; 1-Deoxy-D-xylulose-5-phosphate reductoisomerase; Cinnamaldehydes; Oxidative Heck reaction; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. READ MORE

  3. 3. Design and Synthesis of Aspartic and Serine Protease Inhibitors Targeting the BACE-1 and the HCV NS3 Protease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Fredrik Wångsell; Mats Larhed; Jari Yli-Kauhaluoma; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; BACE-1; transition state mimetic; tertiary hydroxyl group; hydroxyethylene; statine; hydroxyethylamine; hepatitis C; HCV NS3; bioisostere; protease inhibitor.; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection is the primary reason for liver transplantation in industrialized countries. READ MORE

  4. 4. Computational Modelling of Structures and Ligands of CYP2C9

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lovisa Afzelius; Collen Masimirembwa; Ismael Zamora; Anders Karlén; Marcel de Groot; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; CYP2C9; 3D QSAR; GRID; CYP450; pharmacophore modelling; homology modelling; metabolism; competitive inhibitors; CPCA; molecular dynamics simulations; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

    Abstract : CYP2C9 is one of our major drug metabolising enzymes and belongs to the cytochrome P450 (CYP) super family. The aim of this thesis was to gain an understanding of the quantitative structure–activity relationships (QSAR) of CYP2C9 substrates and inhibitors. READ MORE

  5. 5. Computational Studies of Macrocycles and Molecular Modeling of Hepatitis C Virus NS3 Protease Inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hiba Alogheli; Anders Karlén; Anja Sandström; Peter Brandt; Leif Eriksson; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug discovery; HCV NS3 protease; macrocycles; conformational analysis; docking.; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Computational tools are utilized in the drug discovery process to discover, design, and optimize new therapeutics. One important approach is structure-based drug design which relies on knowledge about the 3D structure of the biological target. READ MORE