Search for dissertations about: "l jansson"

Showing result 1 - 5 of 18 swedish dissertations containing the words l jansson.

  2. 1. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

    Author : Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. READ MORE

  4. 2. Bacterial use of allochthonous organic carbon for respiration and growth in boreal freshwater systems

    Author : Martin Berggren; Mats Jansson; Michael L. Pace; Umeå universitet; []
    Keywords : lakes; streams; boreal; bacterial respiration; bacterial production; bacterial growth efficiency; allochthonous organic carbon; low molecular weight compounds; naturgeografi; Physical Geography;

    Abstract : Aquatic systems worldwide receive large amounts of organic carbon from terrestrial sources. This ‘allochthonous’ organic carbon (AlloOC) affects critical physical and chemical properties of freshwater ecosystems, with consequences for food web structures and exchange of greenhouse gases with the atmosphere. READ MORE

  5. 3. Damsel in distress – metabolomics as a novel tool to investigate the effects of wastewater exposure on damselfly larvae

    Author : Jana Späth; Malin L. Nording; Jerker Fick; Stina Jansson; Tuulia Hyötyläinen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biomarkers; ecotoxicology; invertebrates; GC-MS; LC-MS; LC-MS MS; metabolomics; micropollutants; pharmaceuticals; risk assessment; ekotoxikologi; Ecotoxicology; Analytical Chemistry; analytisk kemi;

    Abstract : Aquatic organisms, such as aquatic invertebrates, are exposed to anthropogenic pollutants through their environment. These pollutants, despite their low levels, can adversely affect exposed individuals or even entire ecosystems, especially when present in complex mixtures. READ MORE

  6. 4. Modelling T helper cell activation and development

    Author : Andreas Jansson; Högskolan i Skövde; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; T cells; mathematical models; differentiation; computer simulation; mathematical models; cellular signal transduction; Bioinformatics; Bioinformatik; Natural sciences; Naturvetenskap; Technology; Teknik;

    Abstract : T helper (Th) cell activation and development is one of the most critical events in regulating the adaptive immune response. Understanding its regulation could be of great therapeutical value as many severe diseases are associated with failure in controlling T cell activation and development. READ MORE

  7. 5. HIV-1 variability in relation to host defence mechanisms and disease outcome

    Author : Marianne Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; peptides; seroreactivity; genetic variability; pediatric; disease outcome; biological phenotypes; B-chemokines; coreceptors; V3; V2.;

    Abstract : Genetic variability is a major characteristic of HIV-1. Virus variants evolve rapidly, not only globally, but also within single individuals as a result of an error-prone reverse transcriptase, a rapid virus population turnover and selective pressure from the host. READ MORE