Search for dissertations about: "l-type ca2 channel"

Showing result 16 - 20 of 25 swedish dissertations containing the words l-type ca2 channel.

  2. 16. Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes

    Author : Petronella Kettunen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : mGluR1; mGluR5; spinal cord; modulation; glutamate; NMDA; leak channel; locomotion; endocannabinoids; lamprey.;

    Abstract : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. READ MORE

  4. 17. Environmental input to the pancreatic β-cells - the role of mechanosensitive and other ion channels

    Author : Ye Yingying; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; Tcf7l2; alpha2delta-1; MafA; gamma4; beta-cell function; insulin secretion; dedifferentiation; Ca2 signaling; transcription factor;

    Abstract : Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. READ MORE

  5. 18. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Author : Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. READ MORE

  6. 19. Molecular mechanisms of metal toxicity in neuronal cells

    Author : Annamaria Rossi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Modification of signal transduction by toxic agents can affect cell metabolism and physiological activity, impair cell capacity to adequately respond to hormones and growth stimuli and consequently compromise cell survival. This thesis describes studies on the interactions between toxic metals, at concentrations comparable to environmental exposure, and Ca2+ signalling in neuronal cells. READ MORE

  7. 20. Cytokines and bone : On the role of IL-1 and IL-6 in bone metabolism

    Author : Eva Bornefalk; Uppsala universitet; []
    Keywords : Medical sciences; bone; cytokines; osteoporosis; cAMP; IL-1; IL-6; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Cytokines such as interleukin-1 (IL-l) and interleukin-6 (IL-6) have been implicated in the pathogenesis of postmenopausal osteoporosis. The regulation of cytokine release is unclear, and the mechanism of cytokine induced bone resorption remains to be elucidated. READ MORE